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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (1): 83-86.

• 研究原著 • 上一篇    下一篇

太子参醇提物的抗脂质过氧化作用

袁逸铭, 高湘1, 许爱霞1, 葛斌1   

  1. 兰州医学院第二附属医院耳鼻喉科, 兰州 730030, 甘肃;
    1甘肃省人民医院药剂科, 兰州 730030, 甘肃
  • 收稿日期:2004-10-14 修回日期:2004-11-16 出版日期:2005-01-26 发布日期:2020-11-19
  • 通讯作者: 袁逸铭, 男, 硕士, 副主任医师, 副教授, 硕士研究生导师,主要从事耳聋基础及临床研究。Tel:13309313787
  • 作者简介:葛斌, 男, 学士, 副主任药师, 主要从事抗衰老药基础及临床研究。Tel:0931-8281809 E-mail:gebin1965@sina.com
  • 基金资助:
    甘肃省科学事业科研项目(NoQS041-C33-20)

Effects of alcoholic extract from Radix Pseudostellariae (ERP)on antilipoperoxidation

YUAN Yi-ming, GAO Xiang1, XU Ai-xia1, GE Bin1   

  1. Department of Otorhinolaryngology, the Second Affiliated Hospital, LanzhouMedical College, Lanzhou 730030, Gansu, China;
    1Department of Pharmaceutics, People's Hospital of Gansu Province, Lanzhou 730030, Gansu, China
  • Received:2004-10-14 Revised:2004-11-16 Online:2005-01-26 Published:2020-11-19

摘要: 目的: 研究太子参醇提物的抗脂质过氧化作用。方法: 用自然衰老模型大鼠, 同时灌胃给予生药量2.16、4.32、8.64 g·kg-1·d-1的醇提物, 观察其对自然衰老模型大鼠抗氧化系统的影响。结果: 生药量2.16、4.32、8.64 g·kg-1·d-1的太子参醇提物能使自然衰老模型大鼠血清、肝、肾组织中MDA 不同程度下降, 而SOD 及GSH-PX 活力有不同程度提高。结论: 太子参醇提物有显著清除氧自由基、活性氧及抗脂质过氧化作用。

关键词: 太子参醇提物, 氧自由基, 活性氧, 脂质过氧化, 丙二醛, 超氧化物歧化酶, 谷胱甘肽过氧化物酶, 大鼠

Abstract: AIM: To study the effects of the alcoholic extract from Radix Pseudostellariae(ERP)on antilipoperoxidation.METHODS: The effects of ERP on antioxidation systems of rats were observed by natural senile model rats which were administered the alcoholic extract from 2.16, 4.32, and 8.64 g·kg-1·d-1 of Radix Pseudostellariae.RESULTS: MDA decreased and the activities of SOD and GSH-PX increased in serum, liver and kidneys of natural senile model rats administered ERP.CONCLUSION: ERP have the notable effect on eliminating oxygen free radicals, active oxygen and antilipoperoxidation.

Key words: Radix Pseudostellariae, oxygen free radicals, active oxygen, antilipoperoxidation, malondialdehyde, superoxide dismutase, glutathione peroxidase, rats

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