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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (2): 201-203.

• 研究原著 • 上一篇    下一篇

4.5与7.5月龄雌性Sprague-Dawley 大鼠骨代谢的变化

冯有辉, 许碧连1, 何康, 邹丽宜1, 刘钰瑜1   

  1. 广东医学院生理科学实验室, 1药理教研室, 湛江524023, 广东
  • 收稿日期:2004-11-08 修回日期:2005-01-06 出版日期:2005-02-06 发布日期:2020-11-18
  • 通讯作者: 冯有辉, 男, 实验师, 研究方向:实验动物学。Tel:0759-2388424 E-mail:slkxfyh@xinhuanet.com

Changes of bone in female Sprague-Dawley rats aged 4.5 and 7.5 months

FENG You-hui, XU Bi-lian1, HE Kang, ZOU Li-yi1, LIU Yu-yu1   

  1. Laboratory of Physiological Science, 1Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, China
  • Received:2004-11-08 Revised:2005-01-06 Online:2005-02-06 Published:2020-11-18

摘要: 目的:观察雌性SD 大鼠4.5月龄和7.5月龄时骨代谢的变化。方法:4 月龄雌性SD 大鼠20 只, 随机分2 组, 饲养至4.5月龄和7.5月龄时, 用骨组织形态计量学分别测量胫骨上段(PTM)、腰椎(LV) 及胫骨中段(Tx) 的静态参数和动态参数。结果:与4.5月龄比较, 7.5月龄大鼠PTM、LV、Tx 的骨量无明显变化, 但LV 和Tx 的骨形成参数标记周长百分数(%L.Pm)、矿化沉积率(MAR) 及骨形成率BFR/TV、BFR/BV、BFR/BS 均降低。结论:SD 大鼠在4.5~7.5月龄时, 松质骨和皮质骨的骨量变化不明显, 但腰椎和胫骨中段的骨形成随月龄增加而降低。

关键词: 骨组织形态计量学, 大鼠, 胫骨上段, 腰椎, 胫骨中段

Abstract: AIM: To observe the changes of bone in female Sprague-Dawley rats aged 4.5 and 7.5 months. METHODS: Forty 4-month-old virgin female Sprague-Dawley rats were randomly divided into 4.5 month group and 7.5 month group.Bone histomorphometric analysis of the proximal tibial metaphysis (PTM), tibial shaft (Tx) and the fifth lumbar vertebral body (LV5) was performed in undecalcified sections.RESULTS: There was no significant change in bone volume of PTM, LV5 and Tx between 4.5 and 7.5 months of age.However, the bone formation parameters (%L.Pm, MAR, BFR/TV, BFR/BV, BFR/BS) of LV5 and Tx fall rapidly between 4.5 and 7.5 months of age.CONCLUSION: There is no significant change in cancellous and cortical bone mass, but the bone formation of LV5 and Tx decreases in female Sprague-Dawley rats aged from 4.5 to 7.5 months.

Key words: osteoporosis, bone histomorphometry, rats, cancellous bone, cortical bone

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