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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (3): 318-320.

• 研究原著 • 上一篇    下一篇

中国拟青霉对小鼠免疫性肝损伤的保护作用

成亮, 徐平湘, 唐玉   

  1. 首都医科大学药理学教研室, 北京100054
  • 收稿日期:2004-12-16 修回日期:2005-03-05 出版日期:2005-03-26 发布日期:2020-11-18
  • 通讯作者: 唐玉, 女, 副教授, 主要研究方向:分子生物学与心血管药理学。Tel:010-63051453 E-mail:tang246@sohu.com
  • 作者简介:成亮, 男, 硕士, 助教, 主要研究方向:心血管药理学。Tel:010-63051452 E-mail:chengliang76@sohu.com

Protective effects of CN802 on immunological liver injury in mice

CHENG Liang, XU Ping-xiang, TANG Yu   

  1. Department of Pharmacology, Capital University of Medical Sciences, Beijing 100054, China
  • Received:2004-12-16 Revised:2005-03-05 Online:2005-03-26 Published:2020-11-18

摘要: 目的:研究中国拟青霉(CN-802) 对小鼠免疫性肝损伤的保护作用及其对T 淋巴细胞亚群的影响。方法:小鼠尾静脉注射卡介苗加脂多糖(BCG+LPS) 建立免疫性肝损伤模型, 检测其肝、脾重量和转氨酶活性, 并同时测定血清与肝组织中脂质过氧化物(LPO) 含量及T 淋巴细胞亚群数量。结果:CN-802 连用10 d 后可减轻其增大的肝、脾重量指数, 降低小鼠血清中谷丙转氨酶(ALT) 水平, 降低其血清与肝组织中LPO 含量, 并增加外周血中T 细胞亚群CD4 数量和CD4/CD8 比值。结论:CN-802 对小鼠免疫性肝损伤模型有保护作用, 其作用可能与调节细胞免疫有关。

关键词: 中国拟青霉, 免疫性肝损伤, 卡介苗, 脂多糖, T淋巴细胞亚群

Abstract: AIM: To study the protect effects of paecilomyceps sinensis sp nov (CN-802) on immunological liver injury in mice which induced by BCG+LPS. METHODS: LPS was injected into mice via the tail vein pretreated with BCG.The activity of serum ALT, the weighing indexes of liver and spleen, the levels of LPO in serum and hepatic tissues, and the numbers of subgroup of T lymphocyte were determined respectively.RESULTS: CN-802 at dose of 1.0 g°kg-1 °d-1 decreased the serum ALT level, the liver and spleen-enlarged index and the LPO levels in serum and hepatic tissues.Analysis of CD4/CD8 in the peripheral blood showed that CN-802 increased the number of CD4 lymphocyte and the ratio of CD4/CD8.CONCLUTION: Pretreatment with CN-802 prevents the immunological liver injury induced by BCG+LPG, and the effect of CN802 may be related with the regulatory of immune cells.

Key words: paecilomyceps sinensis sp nov(CN-802), immunological liver injury, BCG, LPS, T-lymphocyte subsets

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