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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (5): 514-517.

• 研究原著 • 上一篇    下一篇

丹参对博莱霉素所致大鼠肺纤维化保护作用的实验研究

陆思静, 刘又宁, 王化洲1   

  1. 中国人民解放军总医院呼吸科, 北京 100853;
    1锦州医学院药理教研室, 锦州 121000, 辽宁
  • 收稿日期:2005-03-06 修回日期:2005-04-19 出版日期:2005-05-26 发布日期:2020-11-19
  • 通讯作者: 刘又宁,男, 教授, 医学博士, 博士生导师, 研究方向:肺部感染性疾病和呼吸衰竭的诊断治疗。Tel:010-66939363 E-mail:liuyn@301hospital.com.cn
  • 作者简介:陆思静, 女, 副教授, 博士研究生, 研究方向:肺部感染性疾病和间质性肺病的基础和临床研究。Tel:010-66936184   E-mail:lsjlsj0996@yahoo .com.cn

Study of Salvia miltiorrhiza on bleomycin-induced pulmonary fibrosis in mice

LU Si-jing, LIU You-ning, WANG Hua-zhou1   

  1. Department of Respiratory Medicine, the PLA General Hospital, Beijing100853, China;
    1Department of Pharmacology,Jinzhou Medical college, Jinzhou121000, Liaoning, China
  • Received:2005-03-06 Revised:2005-04-19 Online:2005-05-26 Published:2020-11-19

摘要: 目的: 探讨丹参对博莱霉素所致大鼠肺纤维化的保护作用及其作用机理。方法: 通过气管内注射博莱霉素复制大鼠肺纤维化模型, 在造模后的d 1 和 d 7 开始给予丹参注射液治疗, 分别在 d 7、d 28 处死大鼠, 对肺组织匀浆中的脂质过氧化物(MDA)、谷胱甘肽(GSH)、羟脯氨酸(HYP) 和肺组织病理学变化测量。结果: 在造模后 d 1 给予丹参注射液治疗能抑制实验性肺纤维化大鼠的肺组织匀浆中的MDA、HYP 异常升高和GSH 的下降, 减轻其肺部的病理损害;在造模后 d 7 给予丹参注射液治疗,丹参治疗组与模型组上述观察指标比较无统计学差异。结论: 丹参注射液可预防大鼠肺纤维化, 对已形成的肺纤维化无逆转作用。

关键词: 丹参, 博莱霉素, 肺纤维化, 肺组织病理学变化, 大鼠

Abstract: AIM: To study protective effects of Salvia miltiorrhiza on bleomycin (BLM)-induced pulmo-nary fibrosis in mice. METHODS: Animal model with pulmonary fibrosis in SD mice was replicated by intratra-cheal injections of bleomycin and Salvia miltiorrhiza in-jection were given after replicated 7th day. Ratswere exe-cuted in 7th and 28th day, MDA, GSH andHYP in lung tissue bomogenate and the lung histopathological change were detected to investigate the effects of Salvia miltior-rhiza injection on lung fibrisis form in different stages. RESULTS: Salviae miltiorrhizae injection given after replicated first day restrained the increase of MDA and HYP, and decreased the GSH of lung tissue bomogenate, and lighten pathological lesion.Salvia miltiorrhiza injec-tion given after replicated the 7th day had no statistical difference between Salvia miltiorrhiza therapy groups and model group.CONCLUSION: Salvia miltiorrhiza injec-tion can prevent mice pulmonary fibrosis from and has no side effects on formative rat pulmonary fibrosis.

Key words: Salvia miltiorrhiza, bleomycetin, pul-monary fibrosis, mice, bleomycin

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