冻干治疗用母牛分支杆菌菌苗对耐多药肺结核患者临床疗效及细胞免疫功能的影响

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (5): 559-561.

冻干治疗用母牛分支杆菌菌苗对耐多药肺结核患者临床疗效及细胞免疫功能的影响

丁卫民, 杨俊行¹, 王光辉²

新乡医学院第一附属医院结核内科,¹胸外科, ²药剂科, 新乡 453100, 河南

收稿日期:2005-02-28 修回日期:2005-04-22 出版日期:2005-05-26 发布日期:2020-11-19
通讯作者: 丁卫民,男, 医学硕士, 副主任医师, 副教授, 研究方向:耐多药结核病临床诊断与治疗。Tel:0373-4402542 E-mail:dwm6606@163.com

Efficacy of freeze-dried M.vaccae vaccine in treatment of patients with multi-drug resistant pulmonary tuberculosis

DING Wei-min, YANG Jun-xing, WANG Guang-hui

Department of Internal Medicine of TuberculosisDisease, the First Affiliated Hospital, Xinxiang Medical College, Xinx-iang453100, Henan, China

Received:2005-02-28 Revised:2005-04-22 Online:2005-05-26 Published:2020-11-19

摘要/Abstract

摘要： 目的: 寻找耐多药结核病免疫治疗的有效药物。方法: 79 例耐多药肺结核患者(MDR-TB) 随机分为治疗组 46 例和对照组 33 例, 两组患者抗痨方案均为“3AkPaThLevl/15PaThLevl”, 治疗组加用“母牛分支杆菌菌苗”。治疗 1~ 3 个月后观察疗效及检测外周血 T 淋巴细胞亚群。结果: 治疗 1、2、3 个月后治疗组患者痰菌阴转率(41.3%、63.0%、80.4%)、X线片肺部病灶吸收好转率(30.4%、50.0%、67.4%)分别优于对照组 (12.1%、27.3%、39.4%, P<0.001;6.1 %、21.2%、27.3%, P<0.05);治疗3 个月后治疗组外周血 ${CD_{3}}^{+}$、${CD_{4}}^{+}$ 及 ${CD_{4}}^{+}$/${CD_{8}}^{+}$ 显著高于对照组(P<0.01), ${CD_{8}}^{+}$ 显著低于对照组(P<0.05)。结论: 母牛分支杆菌菌苗可增强耐多药肺结核患者的细胞免疫功能, 利用患者康复, 可用于耐药结核病免疫治疗。

关键词: 肺结核, 耐多药, T 淋巴细胞亚群, 细胞免疫功能, 免疫疗法, 母牛分支杆菌菌苗

Abstract: AIM: To explore the immunotheraptical drugs for multi-drug resistant pulmonary tuberculosis (MDR-TB). METHODS: 79 patients with MDR-TB were randomly assigned to two groups.46 cases in M. vaccae group were treated with “3AkPaThLevl/15Pa-ThLevL” and M. vaccae, and 33 cases in control group were treated only with“3AkPaThLevl/15PaThLevL”. The clinical effect and T-lymphocyte subsets in patients were observed after being treated for 1, 2 and 3 months, re-spectively. RESULTS: The sputum negative rates (41.3%, 63.0%, and 80.4%) and the X-ray resolu-tion rates (30.4%, 50.0%, and 67.4%) of the M. vaccae group were superior to those (12.1%, 27.3%, and 39.4%, P<0.001) and those (6.1%, 21.2%, and 27.3%, P<0.05) of the control group after being treated for 1, 2 and 3 months.The percent of ${CD_{3}}^{+}$,${CD_{4}}^{+}$and the ratio of ${CD_{4}}^{+}$ ${CD_{8}}^{+}$ of the M. vaccae group were significantly higher than that of the control group (P<0.001), while the percent of ${CD_{8}}^{+}$ of the M. vaccae groupwas significantly lower than that of the control group (P<0.05). CONCLUSION: The M. vaccae can en-hance the cellular immune function of the patients with MDR-TB.

Key words: pulmonary tuberculosis, multi-drug re-sistant, immunotherapy, cellular immune function, T-lym-phocyte subsets, M. vaccae

中图分类号:

R978.3

丁卫民, 杨俊行, 王光辉. 冻干治疗用母牛分支杆菌菌苗对耐多药肺结核患者临床疗效及细胞免疫功能的影响[J]. 中国临床药理学与治疗学, 2005, 10(5): 559-561.

DING Wei-min, YANG Jun-xing, WANG Guang-hui. Efficacy of freeze-dried M.vaccae vaccine in treatment of patients with multi-drug resistant pulmonary tuberculosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(5): 559-561.

[1]	乔红亮, 丁宁, 邓凯红, 刘彬彬, 董传江, 陈晓波, 邹黎黎. 耐甲氧西林金黄色葡萄球菌感染新型控制策略研究新进展[J]. 中国临床药理学与治疗学, 2023, 28(6): 676-687.
[2]	王婷，陈珂，周长平，王义桥，鲁显福，李元海. 精准麻醉对机器人辅助腹腔镜前列腺癌根治术患者围术期细胞免疫功能的影响[J]. 中国临床药理学与治疗学, 2018, 23(2): 175-179.
[3]	杨何，张升，辛艳飞. 肿瘤免疫治疗研究进展[J]. 中国临床药理学与治疗学, 2016, 21(9): 1074-1080.
[4]	王怀冲, 徐颖颖, 张相彩, 张利斌, 曹佳薇, 王翠莲. 联合氯法齐明方案治疗耐多药肺结核的临床研究[J]. 中国临床药理学与治疗学, 2012, 17(11): 1268-1271.
[5]	马婧婧, 周泽文, 颜陶, 伍翔, 王润华, 易静. 固定剂量复合剂(FDC)治疗肺结核的疗效和安全性的Meta分析[J]. 中国临床药理学与治疗学, 2012, 17(10): 1143-1150.
[6]	卢延旭, 陈敏珠. 可溶性鸡Ⅱ型胶原对关节炎大鼠的免疫治疗作用[J]. 中国临床药理学与治疗学, 2004, 9(2): 180-183.
[7]	王勇, 胡杰贵, 胡先纬. 草分枝杆菌联合顺铂治疗恶性胸腔积液的临床评价[J]. 中国临床药理学与治疗学, 2004, 9(1): 107-109.
[8]	金艺凤, 章霞芝, 谢家政, 涂雄文. 含利福霉素钠注射液方案治疗肺结核的有效性和安全性评价[J]. 中国临床药理学与治疗学, 2003, 8(5): 582-584.
[9]	任少华, 鲍行豪. 胸腔内注射金葡液治疗恶性胸水的疗效评价[J]. 中国临床药理学与治疗学, 2003, 8(4): 468-470.
[10]	李琳, 吴航宇, 徐江平. 阿片类药物依赖的治疗学进展[J]. 中国临床药理学与治疗学, 2003, 8(1): 111-114.
[11]	吴敏毓, 米娜, 孙卫民. 补中益气汤拆方组份对脾虚小鼠免疫调节作用^*[J]. 中国临床药理学与治疗学, 1997, 2(2): 114-116.