利福霉素衍生物 Rifabutin 的临床药理研究进展

摘要/Abstract

摘要： Rifabutin( RBT) 是一种类似于利福平( RIF) 的利福霉素衍生物。1992 年被美国 FDA 批准用于治疗和预防发生在 AIDS 患者上的鸟分枝杆菌( MAC) 感染, 随后许多国家相继批准使用该药。但是后来 RBT 已不仅被用于预防治疗MAC, 还用于治疗肺结核以及幽门螺杆菌( HP) 感染。正是由于该药相对于其他利福霉素类药物的高度亲脂性和较弱的 CYP450 诱导作用使得它成功应用于临床多种疾病的治疗, 尤其是和多种抗生素联合用药时, 不仅部分解决了传统抗生素的细菌耐受性问题而且增加了临床联合用药的安全性。本文旨在阐述有关的 Ri- fabutin 的临床药理以及相关方面的研究进展, 以便指导今后临床用药。

关键词: Rifabutin , CYP450 , 药物相互作用 , MAC , 肺结核 , Helicobacter pylori

Abstract: Rifabutin ( RBT) is a rifamycin deriva- tive, like rifampicin ( RIF) , registered for the prophylaxis and treatment of mycobacterium avium complex ( MAC) in patients with AIDS by FDA in 1992 .Subsequently, the drug was approved by many other countries .But now, it is used not only in the prophlaxis and treatment of mycobac- terium avium complex but also in the treatment of pulmo- nary tuberculosis and Helicobacter pylori .For its high li- pophilic characteristic and weak inducing properties com- pare to other rifamycin derivative, it can be applied in treatment with many diseases successfully, especially when combine with other antibiotics, and can solve the problem of traditional antibiotics resistance and increase the clinical safety of combined medical treatment .This paper just shows the progress of clinical pharmacological study and related aspects on rifabutin in order to instruct prescription .

Key words: Rifabutin ;CYP450 ;drug interaction , MAC;pulmonary tuberculosis ;Helicobacter pylori

中图分类号:

R969

李朝旭, 张锦楠, 任爽, 高承英, 孙怡, 王雪. 利福霉素衍生物 Rifabutin 的临床药理研究进展[J]. 中国临床药理学与治疗学, 2006, 11(1): 1-9.

LI Zhao-xu, ZHANG Jin-nan, REN Shuang, GAO Cheng-ying, SUN Yi, WANG Xue. Progress of clinical pharmacological study on rifabutin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(1): 1-9.

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