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中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (6): 684-686.

• 研究原著 • 上一篇    下一篇

蜂王浆类制剂SK初乳素R-1对小鼠免疫功能的影响

谭虎, 钱之玉   

  1. 中国药科大学药理教研室, 南京 210009, 江苏
  • 收稿日期:2006-03-17 修回日期:2006-04-28 出版日期:2006-06-26 发布日期:2020-12-04
  • 通讯作者: 钱之玉,研究方向:生化药理。Tel:025-83321139
  • 作者简介:谭虎,男,硕士,研究方向:生化药理。Tel:025-51532693 E-mail:tanhu2003@hotmail.com

Immunoloregulation effect of SK Royaljelly R-1 in mice

TAN Hu, QIAN Zhi-yu   

  1. Pharmacological Teaching and Research Group of China Pharmaceutical University, Nanjing 210009, Jiangsu, China
  • Received:2006-03-17 Revised:2006-04-28 Online:2006-06-26 Published:2020-12-04

摘要: 目的: 研究蜂王浆类制剂SK 初乳素R-1 对正常小鼠非特异性免疫功能、体液免疫功能、功细胞免疫功能的影响。方法: 以SK 初乳素R-1 连续灌胃给药15 d, 测定小鼠增强小鼠炭末廓清能力、小鼠血清溶血素抗体水平、血清IL-2 含量、抗体生成细胞数、脾淋巴细胞增殖能力等。结果: SK 初乳素R-1各剂量组能增强小鼠炭末廓清率和廓清指数, 各剂量组均能明显升高小鼠血清溶血素抗体水平(P<0.01), 提高小鼠血清IL-2 含量(P<0.01), 促进小鼠抗体细胞形成(P<0.01), 增强ConA 诱导的脾淋巴细胞增殖能力(P<0.01)。结论: 蜂王浆类制剂SK 初乳素R-1 具有增强小鼠免疫功能的作用。

关键词: 蜂王浆, 免疫, 溶血素, 溶血空斑, IL-2

Abstract: AIM: To investigate the effect of SK Royaljelly R-1(SKR)on the innate immunity, humoral immunity, cell immunity in mice.Methods: Observe the effect of SKR on immunity function in mice, the phagocytotic rate and phagocytotic index, haemolysin in serum, plaque forming cell, and the proliferation of splenocyte following administration SKR for 15 days.Result: SK Royaljelly R-1 improved the formulation of serum haemolysin significantly (P<0.01), increased PFC and Il-2 production significantly (P<0.01), and stimulated the splenocyte proliferation stimulated by ConA of normal mice (P<0.01).Conclusion: The results suggeste SKR could potentiate the immunological function of normal mice.

Key words: Royaljelly, immunity, IgM, plaque forming cell, IL-2

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