糖尿病的发病机理与γ-氨基丁酸的作用

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (7): 739-742.

糖尿病的发病机理与γ-氨基丁酸的作用

周吉银, 周世文

中国人民解放军第三军医大学新桥医院国家药品临床研究基地, 重庆 400037

收稿日期:2007-05-08 修回日期:2007-07-02 出版日期:2007-07-26 发布日期:2020-10-27
通讯作者: 周世文, 男, 教授, 博士生导师, 主要从事糖尿病及其并发症的发生机制和防治研究。Tel:023-68755311 E-mail:zhoushiwen2007@yahoo.com.cn
作者简介:周吉银,男,在读博士研究生,主要从事中药抗糖尿病的分子机制研究。Tel:023-68755311 E-mail:gennychou@yahoo.com.cn

Effects of gamma-aminobutyric acid on diabetic etiopathogenesis

ZHOU Ji-yin, ZHOU Shi-wen

Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University of PLA, Chongqing 400037, China

Received:2007-05-08 Revised:2007-07-02 Online:2007-07-26 Published:2020-10-27

摘要/Abstract

摘要： 糖尿病是一种常见的内分泌代谢疾病, 其发病机理尚未完全明确, 与多种因素相关。近年来γ-氨基丁酸在糖尿病形成作用中越来越受到人们的重视, 谷氨酸脱羧酶是γ-氨基丁酸的合成酶抑制剂,是引起糖尿病的早期自身抗原之一。本文分类综述了γ-氨基丁酸与胰岛细胞、糖尿病中枢神经系统之间的关系。

关键词: 糖尿病, 发病机理, γ-氨基丁酸, 谷氨酸脱羧酶

Abstract: Diabetes mellitus is a frequent endocrine disorder disease and its etiopathogenesis is still not completely known, which is caused by several factors.In recent years gamma-aminobutyric acid was believed to have something to do with the formation of diabetes mellitus. The glutamic acid decarboxylase, which is one of the earlier autoantigens causing diabetes mellitus, is the synthetase inhibitor of gamma-aminobutyric acid.The relationship of gamma-aminobutyric acid, islets of langerhans and the central nervous system in diabetes mellitus was reviewed in this paper.

Key words: diabetes mellitus, etiopathogenesis, gamma-aminobutyric acid, glutamate decarboxylase

中图分类号:

R587.1

周吉银, 周世文. 糖尿病的发病机理与γ-氨基丁酸的作用[J]. 中国临床药理学与治疗学, 2007, 12(7): 739-742.

ZHOU Ji-yin, ZHOU Shi-wen. Effects of gamma-aminobutyric acid on diabetic etiopathogenesis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(7): 739-742.

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