复方中药对多囊卵巢综合征模型大鼠糖代谢的影响

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (5): 504-508.

复方中药对多囊卵巢综合征模型大鼠糖代谢的影响

邓阿黎¹, 向楠¹, 周忠明¹, 姜惠中¹, 张亚兵²

¹湖北中医学院附属医院妇产科, 武汉430061, 湖北;
²武汉大学中南医院中医科, 武汉430070, 湖北

收稿日期:2008-12-30 修回日期:2009-04-16 发布日期:2020-11-09
作者简介:邓阿黎, 女, 医学博士, 主治医师, 主要从事中西医结合妇产科疾病的临床、科研及教学工作。Tel:13971220416 E-mail:dengali027 @yahooo.com. cn
基金资助:
武汉市科技厅科技攻关项目(20055102032-4)

Influence of complex prescription traditional Chinese medicine on polycystic ovarian syndrome model rats in glycometabolism

DEN A-li¹, XIANG Nan¹, ZHOU Zhong-ming¹, JIANG Hui-zhong¹, ZHANG Ya-bing²

¹Department of Gynaecology and Obstetrics Affiliated Hospital, Hubei College of TCM, Wuhan 430061, Hubei, China;
²Department of TCM Zhongnan Hospital of Wuhan University, Wuhan 430070, Hubei, China

Received:2008-12-30 Revised:2009-04-16 Published:2020-11-09

摘要/Abstract

摘要： 目的:观察多囊卵巢综合征(PCOS) 模型大鼠体重、空腹血糖(FPG)、胰岛素(INS)、胰岛素样生长因子-1(IGF-1) 的变化, 探讨复方中药对PCOS模型大鼠糖代谢的影响。方法:本实验采用Poresky 法进行造模, 并分别以中、西药进行干预,观察治疗后大鼠体重、血糖的变化以及对血清INS、 IGF-1 的影响。结果:复方中药能降低大鼠体重, 降低血清INS、 IGF-1 水平, 但降低血糖的作用不明显。结论:复方中药能改善PCOS 模型大鼠糖代谢异常情况。

关键词: 中药, 多囊卵巢综合征, 空腹血糖, 胰岛素, 胰岛素样生长因子-1

Abstract: AIM:To observe the changes of weight, fasting plasma glucose (FPG), insulin (INS) and insulin-like growth factor-1 (IGF-1) of polycystic ovary syndrome (PCOS) model rats, and to explore the influence of complex prescription traditional Chinese medicine on glycometabolism. METHODS:PCOS rat models induced by Poresky method were intervened, and the changes of weight, plasma glucose, and the influence of INS and IGF-1 in serum were observed after treatment. RESULTS:The complex prescription traditional Chinese medicine could decrease the weight, the levels of INS and IGF-1 in serum of PCOS model rats, but the glucose-lowering effect was not significant. CONCLUSION:The complex prescription traditional Chinese medicine can improve the glycometabolism abnormal occurrence of PCOS model rats.

Key words: traditional Chinese medicine, polycystic ovarian syndrome, fasting plasma glucose, insulin, insulin-like growth factor-1

中图分类号:

R589

邓阿黎, 向楠, 周忠明, 姜惠中, 张亚兵. 复方中药对多囊卵巢综合征模型大鼠糖代谢的影响[J]. 中国临床药理学与治疗学, 2009, 14(5): 504-508.

DEN A-li, XIANG Nan, ZHOU Zhong-ming, JIANG Hui-zhong, ZHANG Ya-bing. Influence of complex prescription traditional Chinese medicine on polycystic ovarian syndrome model rats in glycometabolism[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(5): 504-508.

参考文献

[1] 吴效科, 周珊英, 苏延华.多囊卵巢综合征患者的胰岛素抵抗[J]. 中华妇产科杂志, 1999, 34(11): 698- 701.
[2] 乐杰.妇产科学[M]. 人民卫生出版社, 2002:376-379.
[3] Dunaif A,Wu X, Lee A, et al.Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS) [J]. Am J Physiol Endocrinol Metab, 2001, 281 (2): E₃92-E₃99.
[4] Marsden PJ, Murdoch AP, Taylor R.Tissue insulin sensitivity and bodyweight in polycystic ovary syndrome [J]. Clin Endocrinol, 2001, 55(2): 191-199.
[5] 初永丽, 孙永玉.PCOS 与胰岛素研究进展[J]. 国外医学妇幼保健分册, 2002, 13(4): 145-147.
[6] Poretsky L, Clemons J, Bogovich K.Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cysts in rats[J]. Metabolism, 1992, 41(8): 903-910.
[7] 陈晓平, 杨文英, 卜石, 等.罗格列酮和二甲双胍对高脂饲养造成的胰岛素抵抗的影响[J]. 中华内科杂志, 2004, 43(4): 280-283.
[8] 蔡丽慧, 张秀兰, 刘云莲.中西医结合治疗多囊卵巢综合征的临床研究[J]. 中医函授通讯, 1997, 16 (3): 38.
[9] 俞瑾, 孙月丽, 邵公权, 等.补肾化痰治疗多囊卵巢综合征中对下丘脑-垂体-卵巢功能的调节[J]. 中西医结合杂志, 1986, 6(4): 218.
[10] 罗元恺.实用中医妇科学[M]. 上海:上海科学技术出版社, 1996: 290.
[11] 中国中西医结合研究会第一次全国活血化瘀学术会议:血瘀证诊断试行标准[S]. 中西医结合杂志, 1983, 3(3): 封二.
[12] 周璐, 章巧萍, 徐孝平, 等.徐小玉生精汤对雄激素致无排卵模型大鼠卵巢功能及形态学的影响[J]. 浙江中医药大学学报, 2006, 30(6): 621-622.
[13] 黄荷凤, 郦美根.多囊卵巢综合征和高雄激素血症[J]. 中国实用妇科与产科杂志, 2002, 18(11): 647- 648.
[14] 徐雯, 王元佩, 赵采, 等.多囊卵巢综合征患者血清卵泡液中胰岛素样生长因子-1 水平研究[J]. 福建医药杂志, 2004, 26(4): 113-114.
[15] 郝敏, 范林霄, 杨燕生.多囊卵巢综合征患者血清胰样生长因子-1 的检测及临床意义[J]. 中国实用妇科与产科杂志, 2005, 21(3): 181-182.
[16] 邓阿黎, 周忠明, 向楠, 等.复方中药对多囊卵巢综合征模型大鼠血清性激素、瘦素水平的影响[J]. 中国临床药理学与治疗学, 2008, 13(10): 1139-1143.
[17] 邓阿黎, 周忠明, 张亚兵, 等.补肾化痰祛瘀中药对PCOS 模型大鼠卵巢组织形态学作用的实验研究[J]. 中国药师, 2009, 12(2): 143-145.