中药对细胞色素P450代谢影响的研究进展

中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (6): 697-700.

中药对细胞色素P450代谢影响的研究进展

谢瑞芳, 周昕

上海中医药大学附属龙华医院药剂科, 上海 200032

收稿日期:2008-12-12 修回日期:2009-05-24 出版日期:2009-06-26 发布日期:2020-10-27
通讯作者: 周昕, 女, 博士, 副主任药师, 硕士研究生导师, 研究方向:中药制剂工艺与质量标准研究。Tel:13917171394 E-mail:zhouxinren@yahoo.com.cn
作者简介:谢瑞芳,女,硕士,药师,研究方向:中药制剂工艺与质量标准研究。Tel:13402133019 E-mail:hairan-xie@sohu.com
基金资助:
上海中医药大学校级课题《中药黄芪对2 型糖尿病患者CYP450酶系活性的影响》资助

Research progress on traditional Chinese medicine affecting the metabolism of cytochrome P450

XIE Rui-fang, ZHOU Xin

Department of Pharmacy, Longhua Hospital, Shanghai University of TCM, Shanghai 200032, China

Received:2008-12-12 Revised:2009-05-24 Online:2009-06-26 Published:2020-10-27

摘要/Abstract

摘要： 细胞色素P450(CYP) 是微粒体混合功能氧化酶中最重要的一族, 在外源性物质和内源性物质的代谢中起着极其重要的作用。本文通过查阅国内外相关文献, 对近几年关于中药对CYP 酶影响的研究进展作一综述, 分别介绍了CYP1A1、CYP1A2、CYP2A6、CYP2C、CYP2D6、CYP2E1、CYP3A4 和CYP3A4 这几种主要的药物代谢酶。研究CYP 酶对新药筛选、给药个体化等具有重要意义。

关键词: 中药, 细胞色素P450, 研究进展

Abstract: Cytochrome P450 is one of the microsomal mixed function oxidase, and plays an important role in the metabolism of exogenous and endogenous material.Lots of domestic and overseas relative literatures were red, the article summarized the research progress of traditional Chinese medicine affecting the metabolism of CYP in recent years.Eight main drugmetabolizing enzymes were respectively introduced, including CYP1A1, CYP1A2, CYP2A6, CYP2C, CYP2D6, CYP2E1, CYP3A4 and CYP3A4.It is important to research CYP450 for drug screening, individual administration.

Key words: traditional Chinese medicine, CYP, research in progress

中图分类号:

R285.6

谢瑞芳, 周昕. 中药对细胞色素P450代谢影响的研究进展[J]. 中国临床药理学与治疗学, 2009, 14(6): 697-700.

XIE Rui-fang, ZHOU Xin. Research progress on traditional Chinese medicine affecting the metabolism of cytochrome P450[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(6): 697-700.

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