青蒿素及其衍生物药理作用研究有关进展

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (5): 572-576.

青蒿素及其衍生物药理作用研究有关进展

李斌, 周红

第三军医大学药学院药理学教研室,重庆 400038

收稿日期:2010-03-29 修回日期:2010-04-21 出版日期:2010-05-26 发布日期:2020-09-16
通讯作者: 周红,女, 博士,教授,博士生导师,研究方向: 抗炎及抗感染药物药理学。Tel: 023-68752266 E-mail: zhouh64@163.com
作者简介:李斌,男, 博士,讲师,研究方向: 抗炎及抗感染药物药理学。Tel: 023-68752265 E-mail: libin6033@sina.com
基金资助:
国家自然科学基金(30772628);重庆市自然科学基金计划项目重点项目(CSTC,2009BA5008)

Advances on the study of the pharmacological effects of artemisinin and its derivatives

LI Bin, ZHOU Hong

Department of Pharmacology, College of Pharmaceutical, Third Military Medical University, Chongqing 400038, China

Received:2010-03-29 Revised:2010-04-21 Online:2010-05-26 Published:2020-09-16

摘要/Abstract

摘要： 青蒿素属倍半萜内酯化合物,其衍生物主要有双氢青蒿素、青蒿琥酯、蒿甲醚和蒿乙醚,现在临床上主要用于治疗疟疾。随着对青蒿素及其衍生物药理作用的研究不断深入,除抗疟作用外,近年来又相继报道了抗炎、抗细菌脓毒症、抗肿瘤、放射增敏、抗菌增敏、抗组织纤维化等作用。笔者在此对国内外近年发现的青蒿素及其衍生物药理作用研究的最新现状作一综述。

关键词: 青蒿素, 衍生物, 药理作用

Abstract: Artemisinin is a sesquiterpene lactone compounds, their derivatives include mainly dihydroartemisinin, artesunate, artemether and Artemisia ether. These drugs are now mainly used for clinical treatment of malaria. With the pharmacological action of artemisinin and its derivatives have been further studied, except antimalarial effects, researchers have found their anti-inflammatory, anti-sepsis, antitumor, radiosensitization, antimicrobial sensitivity, anti-fibrosis effects in recent years. Here, we collect and review the most newly pharmacological effects of artemisinin and its derivatives all over the world in past years.

Key words: Artemisinin, Derivates, Pharmacological action

中图分类号:

李斌, 周红. 青蒿素及其衍生物药理作用研究有关进展[J]. 中国临床药理学与治疗学, 2010, 15(5): 572-576.

LI Bin, ZHOU Hong. Advances on the study of the pharmacological effects of artemisinin and its derivatives[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(5): 572-576.

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