酸敏感离子通道3在关节炎疼痛中的作用

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (9): 1064-1068.

酸敏感离子通道3在关节炎疼痛中的作用

李霞¹, 袁凤来¹, 陈飞虎², 赵懿青¹, 陆伟国¹, 胡伟², 张腾越², 吴繁荣²

¹南通大学第三附属医院,无锡 214041,江苏;
²安徽医科大学药学院,合肥 230032,安徽

收稿日期:2010-04-09 修回日期:2010-08-25 出版日期:2010-09-26 发布日期:2020-09-17
作者简介:李霞,女,助教,研究方向:骨代谢疾病、分子药理学。Tel: 0510-82607391, E-mail: lixia.ahmu.cn@163. com; 袁凤来,男,助教,研究方向:骨代谢疾病、分子药理学。Tel: 0510-82603332, E-mail: bjjq88@163. com; 陈飞虎,男,博士,教授,博士生导师,研究方向:分子药理学。Tel: 0551-25161115, E-mail: cfhchina@sohu. com
基金资助:
国家自然科学基金资助(30901526;30873080)

Effects of acid-sensing ion channels 3 subunit in arthritis pain

LI Xia¹, YUAN Feng-Lai ¹, CHEN Fei-Hu², ZHAO Yi-qing¹, LU Wei-Guo¹, HU Wei², ZHANG Teng-yue², WU Fan-rong²

¹The Third Hospital Affiliated to Nantong University, Wuxi 214041, Jiangsu, China;
²College of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China

Received:2010-04-09 Revised:2010-08-25 Online:2010-09-26 Published:2020-09-17

摘要/Abstract

摘要： 疼痛相关的酸敏感离子通道3(Acid-sensing ion channels 3, ASIC3)主要分布在周围神经系统,是对pH值改变最敏感的酸受体。最近,越来越多的研究证实,在脊髓背根神经节(DRG)丰富表达的ASIC3,与痛觉及伤害性感受密切相关,在慢性炎性疼痛的病理过程中发挥重要的作用。研究表明在炎性痛模型中可以上调脊髓背角ASIC3在转录和蛋白水平的表达;阻断或敲除ASIC3基因 (ASIC3-/-)能明显抑制炎症性关节痛。上述各点提示,在生理或病理情况下,脊髓背角ASIC3对脊髓水平的感觉信息传递特别是痛觉的传导可能发挥着重要作用,这可能是关节炎疼痛的治疗靶点。本文将ASIC3的生物学特征以及它在关节炎疼痛和治疗中的作用作一综述。

关键词: 酸敏感离子通道3, 炎症, 疼痛, 痛觉增敏, 背根神经节, 靶点

Abstract: Pain-related acid-sensing ion channels 3 (ASIC3), the most sensitive acceptor to such a pH change, has been shown to be predominantly expressed in the peripheral nervous system. Over recent years, there has been increased evidence that ASIC3 may lead to the pathogenesis of chronic inflammatory pain diseases because that it is predominantly expressed in dorsal root ganglia (DRG) neurons making it a good candidate for a pain sensor. It has been shown that increased expression of ASIC3 mRNA and protein was found in DRG of rodents with inflamed joints and ASIC3 gene knock-out mice (ASIC3-/-) exhibited no enhanced hyperalgesia in inflamed joint. These findings suggest that under the physiological or pathological circumstance, ASIC3 have an important biological effect on the sensor information, especially pain transmission of the spinal cord level, which might be a promising therapeutic target for arthritis pain. In this study, we will briefly discuss the biological features of ASIC3 and summarize recent advances on the role of ASIC3 in the arthritis and during the course of its treatment.

Key words: ASIC3, Inflammation, Pain, Hyperalgesia, DRG, Therapeutic target

中图分类号:

R962

李霞, 袁凤来, 陈飞虎, 赵懿青, 陆伟国, 胡伟, 张腾越, 吴繁荣. 酸敏感离子通道3在关节炎疼痛中的作用[J]. 中国临床药理学与治疗学, 2010, 15(9): 1064-1068.

LI Xia, YUAN Feng-Lai , CHEN Fei-Hu, ZHAO Yi-qing, LU Wei-Guo, HU Wei, ZHANG Teng-yue, WU Fan-rong. Effects of acid-sensing ion channels 3 subunit in arthritis pain[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(9): 1064-1068.

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