新颖肿瘤抑制基因染色质修饰蛋白1A的研究进展

中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (9): 1069-1073.

新颖肿瘤抑制基因染色质修饰蛋白1A的研究进展

由振强, 辛艳飞, 韩滨, 宣尧仙

浙江省医学科学院安全性评价研究中心,杭州 310013,浙江

收稿日期:2010-07-19 修回日期:2010-08-20 出版日期:2010-09-26 发布日期:2020-09-17
通讯作者: 宣尧仙,女,研究员,硕导,研究方向:药理学、毒理学。E-mail: nndsvc@mail.hz.zj.cn
作者简介:由振强,男,助理研究员,研究方向:分子毒理学。Tel: 0576-87568012, E-mail: youzq1979@163.com
基金资助:
国家自然科学基金(30901759);浙江省医药卫生科学基金(2009B001)资助项目

Research advances in a novel tumor suppressor gene Chromatin modifying protein 1A

YOU Zhen-qiang, XIN Yan-fei, HAN Bin, XUAN Yao-xian

Research Center of Safety Evaluation for New Drugs,Zhejiang Academy of Medical Sciences,Hangzhou 310013,Zhejiang,China

Received:2010-07-19 Revised:2010-08-20 Online:2010-09-26 Published:2020-09-17

摘要/Abstract

摘要： 染色质修饰蛋白1A(Chromatin modifying protein 1A,Chmp1A)属于转运必需内吞体分选复合物-III复合物(ESCRT-III)家族成员,在多泡体(MVB)的形成过程中起着关键作用。最近研究发现,在人类多种肿瘤组织中Chmp1A表达明显降低,且低表达Chmp1A的正常细胞易于肿瘤化。Chmp1A主要聚集在胞质和核基质,对染色质结构、细胞周期和囊泡转运均有重要影响,且有研究表明,Chmp1A 可能是一种PcG蛋白。Chmp1A的失活与多种肿瘤的发生、发展关系密切,是一种新颖肿瘤抑制基因。

关键词: 染色质修饰蛋白1A, 肿瘤, 肿瘤抑制

Abstract: Chromatin modifying protein 1A (Chmp1A) is a member of the Endosomal Sorting Complex Required for Transport (ESCRT-III) family that was shown to function in endosome-mediated trafficking via multivesicular body (MVB) formation and sorting.The expression of Chmp1A is markedly decreased in many tumors. Loss of Chmp1A expression in normal cells results in tumors formation in vivo. Chmp1A is mainly located in cytoplasmic and nuclear matrix, and participates in mitotic chromosome condensation, cell-cycle progression, and vesicle trafficking. Recent studies suggest that Chmp1A is a candidate PcG protein. Chmp1A is a novel tumor suppressor gene, which inactivation is related to the initiation and progression of several tumors.

Key words: Chmp1A, Tumor, Tumor suppressio

中图分类号:

R730.2

由振强, 辛艳飞, 韩滨, 宣尧仙. 新颖肿瘤抑制基因染色质修饰蛋白1A的研究进展[J]. 中国临床药理学与治疗学, 2010, 15(9): 1069-1073.

YOU Zhen-qiang, XIN Yan-fei, HAN Bin, XUAN Yao-xian. Research advances in a novel tumor suppressor gene Chromatin modifying protein 1A[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(9): 1069-1073.

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