麻醉药的抗炎抗感染功效及其作用靶点研究进展

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (8): 940-943.

麻醉药的抗炎抗感染功效及其作用靶点研究进展

潘庆军¹, 刘渊²

¹广东医学院附属医院肾脏疾病研究所,湛江 524001,广东;
²香港大学李嘉诚医学院,香港 999077,中国

收稿日期:2012-04-20 修回日期:2012-06-12 出版日期:2012-08-26 发布日期:2012-08-14
作者简介:潘庆军,男,博士,讲师,研究方向:抗感染免疫和自身免疫疾病。Tel: 0759-2387164 E-mail: stilwapan@gmail.com
基金资助:
国家自然科学基金项目(30671970)

Advances in search for anti-inflammatory and anti-infective of anesthetics and their targets

PAN Qing-jun¹, LIU Yuan²

¹Institute of Nephrology, Affiliated Hospital of Guangdong Medical College, Zhangjiang 524001, Guangdong, China;
²Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine,University of Hong Kong, Hong Kong 999077, China

Received:2012-04-20 Revised:2012-06-12 Online:2012-08-26 Published:2012-08-14

摘要/Abstract

摘要： 除在手术中发挥止痛与肌松弛等作用外,麻醉药的抗急性炎症和抗感染的功效日益受到关注,尤其是对内毒素血症及内毒素性休克动物的保护作用。研究显示不同的麻醉药具有不同的精确作用靶点,因此推测麻醉药的抗炎抗感染作用机制也不完全一样。本文主要介绍麻醉药的抗炎抗感染功效及其作用靶点研究进展。

关键词: 麻醉药, 抗炎, 抗感染, 靶点

Abstract: Despite pain relief and muscle relaxation in surgery, effects of anesthetics on anti-inflammatory and anti-infective efficacy gains a growing concern, especially the protection in endotoxemia and endotoxin shock of animals. Studies have shown that different sedation agents have different precision targets, it suggests that the mechanism of specific anesthetics will not be the same. The aim of this paper is to provide an overview of existing research studies and their approaches concerning the effects of anesthetics on anti-inflammatory and anti-infective efficacy and their targets.

Key words: Anesthetics, Anti-inflammatory, Anti-infective, Target

中图分类号:

R96
文

潘庆军, 刘渊. 麻醉药的抗炎抗感染功效及其作用靶点研究进展[J]. 中国临床药理学与治疗学, 2012, 17(8): 940-943.

PAN Qing-jun, LIU Yuan. Advances in search for anti-inflammatory and anti-infective of anesthetics and their targets[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(8): 940-943.

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