甲状腺激素和肝脏胰岛素抵抗的研究进展

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (3): 356-360.

• 综述与讲座 • 上一篇

甲状腺激素和肝脏胰岛素抵抗的研究进展

蒋励¹, 贺碧霞¹, 丁启龙²

¹中国药科大学,南京 211198,江苏
²中国药科大学药学医学基础实验教学中心,南京 211198,江苏

收稿日期:2013-01-25 修回日期:2013-03-15 出版日期:2013-03-26 发布日期:2013-04-02
通讯作者: 丁启龙,通信作者,男,副教授,研究生导师,研究方向:心血管药理学。Tel: 025-86185309 E-mail: dqlcpu@163.com
作者简介:蒋励,女,在读硕士研究生,研究方向:胰岛素抵抗与内分泌。

Study on the relationship between thyroid hormones and hepatic insulin resistance

JIANG Li¹, HE Bi-xia¹, DING Qi-long²

¹China Pharmaceutical University,Nanjing 211198,Jiangsu,China
²Experimental and Teaching Center of Medical Basis for Pharmacy,China Pharmaceutical University,Nanjing 211198,Jiangsu,China

Received:2013-01-25 Revised:2013-03-15 Online:2013-03-26 Published:2013-04-02

摘要/Abstract

摘要： 胰岛素抵抗是指胰岛素的外周靶组织和细胞对内源性或外源性胰岛素的敏感性和反应性降低,导致生理剂量的胰岛素产生低于正常的生理效应,临床表现为高胰岛素血症、高血糖、高血压、高血脂等代谢紊乱。正常甲状腺功能状态是维持正常糖脂代谢和人体胰岛素敏感性的一个重要因素,甲状腺激素水平的改变对肝脏胰岛素抵抗形成有重要作用。本文就目前关于甲状腺激素与肝脏胰岛素抵抗的关系进行综述,以期为后续的研究进展提供较为系统的文献基础。

关键词: 甲状腺激素, 胰岛素抵抗, 肝脏, 糖脂代谢

Abstract: Insulin resistance means the peripheral target tissue and cells of insulin have a decreased effect on endogenous or exogenous insulin sensitivity and reactivity, leading to physiological dose of insulin producing physiological effects below normal and appearing clinical manifestations of hyperinsulinemia, high blood sugar, high blood pressure, high cholesterol and other metabolic disorders. The normal thyroid function status is an important factor to maintain the normal glucolipid metabolism and insulin sensitivity and thyroid hormone levels are important in the formation of hepatic insulin resistance. This article summarizes the present study of the relationship between thyroid hormones and hepatic insulin resistance, aiming to provide a systematic and fundamental document for the follow-up research.

Key words: Thyroid hormone, Insulin resistance, Liver, Glucolipid metabolism

中图分类号:

蒋励, 贺碧霞, 丁启龙. 甲状腺激素和肝脏胰岛素抵抗的研究进展[J]. 中国临床药理学与治疗学, 2013, 18(3): 356-360.

JIANG Li, HE Bi-xia, DING Qi-long. Study on the relationship between thyroid hormones and hepatic insulin resistance[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(3): 356-360.

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甲状腺激素和肝脏胰岛素抵抗的研究进展

Study on the relationship between thyroid hormones and hepatic insulin resistance

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