有机阳离子转运体的研究进展

摘要/Abstract

摘要： 有机阳离子转运体(Organic cation transporters, OCTs)参与许多重要内源性物质和药物的体内转运过程,其作用愈来愈被人们所重视。本文就近年来有关OCTs与内源性物质和药物的相互作用、OCTs的表达水平调节及基因多态性的影响等方面的研究进展进行综述。

关键词: 有机阳离子转运体, 药物相互作用, 基因多态性

Abstract: Nowadays, more and more attentions have been attached to the importance of organic cation transporters (OCTs). OCTs has involved in the transmembrane transport of numerous significant endogenous and exogenous substances including many clinical drugs. Therefore, recent progress on the interactions between OCTs and these substances, the regulation of OCTs expression and the influence of OCTs polymorphism are reviewed in this paper.

Key words: Organic cation transporters, Drug-drug interactions, Gene polymorphism

中图分类号:

R969.1

李晓楠, 陈佳音, 孙晓琳, 张永杰, 文彦丽, 王岁楼, 陈西敬. 有机阳离子转运体的研究进展[J]. 中国临床药理学与治疗学, 2013, 18(8): 954-960.

LI Xiao-nan, CHEN Jia-yin, SUN Xiao-lin, ZHANG Yong-jie, WANG Chun-feng, WEN Yan-li, WANG Sui-loU, CHEN Xi-jing. Research progress of organic cation transporters[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(8): 954-960.

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