20-羟-二十烷四烯酸在糖尿病心血管并发症中的作用

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (8): 950-953.

20-羟-二十烷四烯酸在糖尿病心血管并发症中的作用

吕洪乐, 付萍, 李华

大连医科大学药学院药理教研室,大连 116044,辽宁

收稿日期:2013-01-17 修回日期:2013-06-18 出版日期:2013-08-26 发布日期:2013-07-31
通讯作者: 李华,女,博士,副教授,硕士生导师,研究方向:心血管药理学& 糖尿病药理学。Tel: 0411-86110406 E-mail: dllihua@126.com
作者简介:吕洪乐,男,硕士研究生,研究方向:心血管药理学& 糖尿病药理学。E-mail: 505161857@qq.com

Role of 20-HETE in diabetic cardiovascular complications

LV Hong-le, FU Ping, LI Hua

Department of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, Liaoning, China

Received:2013-01-17 Revised:2013-06-18 Online:2013-08-26 Published:2013-07-31

摘要/Abstract

摘要： 糖尿病是以高血糖为特征的代谢紊乱综合征,其心血管并发症是导致糖尿病患者致残、致死的主要原因。20-羟-二十烷四烯酸(20-hydroxyeicosatetraenoic acid,20-HETE)是近年来发现的花生四烯酸(Arachidonic acid,AA)第三条代谢通路,细胞色素P-450(Cytochrome P-450,CYP450)途径的活性代谢产物。现有研究表明其在调节肾功能和血管平滑肌紧张度中起到重要作用,但对20-HETE与糖尿病的关系研究甚少。本文对近年来国际上20-HETE与糖尿病心血管并发症的研究报道进行综述。

关键词: 20-羟-二十烷四烯酸, 糖尿病, 血管平滑肌细胞, 内皮细胞, 肾脏, 高血压

Abstract: Diabetes is a metabolic disorder syndrome characterized by hyperglycemia and cardiovascular complications are major causes of death and disability. 20-hydroxyeicosatetraenoic acid (20-HETE) is the newly-identified active metabolite of arachidonic acid (AA) catalyzed by cytochrome P-450 (CYP450), which is called as the third metabolic pathway of AA. Recent researches suggest its significant role in the regulation of renal function and vascular smooth muscle tension. But there is few reports about the relationship of 20-HETE and diabetes. The present article reviewed the international researches on 20-HETE and diabetic cardiovascular complications published in recent years.

Key words: 20-HETE, Diabetes, Vascular smooth muscle cells, Endothelial cells, Kidney, Hypertension

中图分类号:

吕洪乐, 付萍, 李华. 20-羟-二十烷四烯酸在糖尿病心血管并发症中的作用[J]. 中国临床药理学与治疗学, 2013, 18(8): 950-953.

LV Hong-le, FU Ping, LI Hua. Role of 20-HETE in diabetic cardiovascular complications[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(8): 950-953.

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