白血病动物模型研究进展

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (12): 1416-1421.

白血病动物模型研究进展

杨林承, 何艺磊, 李卫东

北京大学医学部基础医学院药理学系,北京 100191

收稿日期:2013-04-12 修回日期:2014-02-12 发布日期:2020-07-20
通讯作者: 李卫东,通信作者,女,博士,副教授,硕士生导师。Tel:13641280216 E-mail:lwdpharma@126.com
作者简介:杨林承,男,本科在读,于2011年参加“北京大学医学部基础医学院创新人才培养计划”项目。Tel:13611361556 E-mail:yanglinchengylc@163.com
基金资助:
北京市自然科学基金资助项目(7102100);国家自然科学基金资助项目(81173069);国家基础科学人才培养基金(J1030831/J0108)

Research advances of the leukemia animal models

YANG Lin-cheng, HE Yi-lei, LI Wei-dong

Department of Pharmacology, Peking University Health Science Center, Beijing 100191, China

Received:2013-04-12 Revised:2014-02-12 Published:2020-07-20

摘要/Abstract

摘要： 在研究治疗肿瘤的药物过程中,白血病动物模型常被选用。早期的白血病动物模型与人类白血病的拟合度不高,但随着对白血病发病机制研究的不断深入和技术的不断进步,白血病动物模型与人类白血病的拟合度明显改善。本文介绍几种白血病鼠类动物模型及研究进展。研究与人类白血病的拟合度高的动物模型对于抗癌药物的研发起着非常重要的作用。

关键词: 白血病, 动物模型, 进展

Abstract: Leukemia animal models are often used in the research of cancer drug. Early leukemia animal models had low degree of fitting to the condition of human leukemia. However, as the research of pathogenesis of leukemia developed, the degree of fitting is getting better. A few kinds of leukemia mouse models and their research advances are shown in this review. The research of the high similarity leukemia animal models will contribute to the improved understanding and treatment of these cancers.

Key words: leukemia, animal model, advance

中图分类号:

R733.7

杨林承, 何艺磊, 李卫东. 白血病动物模型研究进展[J]. 中国临床药理学与治疗学, 2014, 19(12): 1416-1421.

YANG Lin-cheng, HE Yi-lei, LI Wei-dong. Research advances of the leukemia animal models[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(12): 1416-1421.

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