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中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (3): 356-360.

• 综述与讲座 • 上一篇    

非诺贝特在心肌肥大机制中的研究进展

黄金贤, 周四桂   

  1. 广东药学院临床药学系,广州 510006,广东
  • 收稿日期:2013-07-22 修回日期:2014-03-18 出版日期:2014-03-26 发布日期:2014-04-10
  • 通讯作者: 周四桂,女,博士,副教授,研究方向:心血管药理学。Tel: 020-39352123 E-mail: susanzsg@163.com
  • 作者简介:黄金贤,女,在读研究生,研究方向:心血管药理学。
  • 基金资助:
    国家自然科学基金青年科学基金资助项目(81000072)

Research progress of fenofibrate in the mechanism of myocardial hypertrophy

HUANG Jin-xian, ZHOU Si-gui   

  1. Department of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
  • Received:2013-07-22 Revised:2014-03-18 Online:2014-03-26 Published:2014-04-10

摘要: 非诺贝特作为调脂类药物,在其机制尚未明确阐释之前,目前已有大量基础研究证实其能抑制心肌肥大,对心肌肥大的临床治疗提供了广阔的视野与理论基础。综述非诺贝特在治疗心肌肥大中的可能机制,进一步了解非诺贝特在调节血脂之外的其他药理作用,对展望探讨其更深入的信号通路机制及更广的治疗前景有着重要的意义。

关键词: 非诺贝特, 心肌肥大, 过氧化物酶体增殖剂激活受体α, 机制

Abstract: As lipid-regulating drug, the mechanism of fenofibrate is not clear. A large number of basic studies have been confirmed that it can inhibit myocardial hypertrophy. The clinical treatment of myocardial hypertrophy has provided a broad field of vision and theoretical basis. The treatment of fenofibrate in myocardial hypertrophy through the possible mechanism was reviewed. Further understanding of the other pharmacological effects of fenofibrate except for regulating blood lipid is needed. Further signal pathway and broader prospects are expected.

Key words: fenofibrate, myocardial hypertrophy, peroxisome proliferator activated receptor α, mechanism

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