阿司匹林对多囊卵巢综合征大鼠炎症反应的影响

中国临床药理学与治疗学 ›› 2015, Vol. 20 ›› Issue (1): 19-23.

阿司匹林对多囊卵巢综合征大鼠炎症反应的影响

李维宏¹, 李斌²

¹重庆医科大学附属第一医院生殖健康与不孕症专科,重庆 400016;
²第三军医大学药学院药理学教研室,重庆 400038

收稿日期:2014-02-27 修回日期:2014-06-18 发布日期:2020-07-20
作者简介:李维宏,女,博士,主治医师,主要从事妇产科辅助生育及抗炎免疫基础研究工作。Tel:023-89012397 E-mail:285665498@qq.com
基金资助:
重庆市卫生局医学科研计划项目(2012-2-029)

Effects of aspirin on inflammatory responses in PCOS rats

LI Wei-hong¹, LI Bin²

¹Reproductive Health and Infertility Center, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;
²Department of Pharmacology, College of Pharmaceutical, Third Military Medical University, Chongqing 400038, China

Received:2014-02-27 Revised:2014-06-18 Published:2020-07-20

摘要/Abstract

摘要： 目的: 探讨阿司匹林对多囊卵巢综合征(polycystic ovarian syndrome, PCOS)大鼠炎症反应的影响及其机制。方法: 采用人绒毛膜促性腺激素和胰岛素皮下注射建立PCOS模型,观察阿司匹林对PCOS大鼠体质量、卵巢重量和病理、血清TNF-α、IL-6、胰岛素水平及卵巢TNF-α、IL-6 mRNA表达的影响。结果: 阿司匹林可剂量依赖性降低PCOS大鼠体质量和卵巢重量,减轻卵巢病理改变,血清TNF-α、IL-6、胰岛素含量和卵巢TNF-α、IL-6表达水平亦明显降低。结论: 阿司匹林可通过其抗炎作用对PCOS大鼠产生保护作用。

关键词: 阿司匹林, 多囊卵巢综合征, 炎症反应

Abstract: AIM: To study the effects of aspirin on inflammatory responses in polycystic ovarian syndrome (PCOS) rats. METHODS: Combined administration of human HCG and insulin was used for establishing PCOS rat model, PCOS rat weight, ovarian weight, morphology. The effects of aspirin on the levels of serum TNF-α, IL-6 and insulin and the expression of IL-6 and TNF-α mRNA in ovarian tissue were observed. RESULTS: Aspirin treatment significantly reduced the rat weight and ovary weight in PCOS rats, the ovarian pathological changes, levels of TNF-α, IL-6 and insulin in serum and expressions of IL-6 and TNF-α mRNA in ovarian tissue were obviously reduced compared with the PCOS rats. CONCLUSION: Aspirin therapy has protective effect on PCOS rats and the effect is closely related to its anti-inflammatory effect.

Key words: aspirin, polycystic ovary syndrome, inflammatory responses

中图分类号:

R965.2

李维宏, 李斌. 阿司匹林对多囊卵巢综合征大鼠炎症反应的影响[J]. 中国临床药理学与治疗学, 2015, 20(1): 19-23.

LI Wei-hong, LI Bin. Effects of aspirin on inflammatory responses in PCOS rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(1): 19-23.

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