关键词: 口服升白细胞药物, 化疗, 白细胞减少, 小鼠

Abstract: AIM: To evaluate the effects of five routine oral drugs for the treatment of chemotherapy related leukocytopenia in mice experimental study.METHODS: Mice models of chemotherapy related leukocytopenia were established by intraperitoneal injection of cyclophosphamide (CTX). Mice were treated by Qijiao Shengbai capsules (Q), Weixuening granule (W), Compound soap alum pill (S), berbamine (B), leucogen(L), respectively, and Granulocyte Colony-Stimulating Factor (G-CSF) was used as positive control at the same time. Hemocytes were calculated by hematology analyzer and organs were weighted through anatomy for calculating organ indexes.RESULTS: No significant difference in death rate was found in various groups of Mice. Regarding to the effects of promoting peripheric leukocytes, G-CSF, L, B, W, Q and S were in turn of effectiveness from high to low, in which no significant increase in leukocytes was found in Q and S groups. In addition, peripheric erythrocytes, hemoglobin, and platelets were also increased in L and B groups. Organ indexes were calculated, of which heart, spleen, and lung were affected mostly by drugs. As to single drug, B had the least effect on organs and S was the most.CONCLUSION: The best effect of promoting peripheric leukocytes was G-CSF, and L was the second. Furthermore, B possessed the effect of promoting peripheric hemocytes including leukocytes, erythrocytes, platelets, and had the least effect on organ index.

Key words: oral drugs for promoting peripheric leukocytes, chemotherapy, leukocytopenia, mice