关键词: 医嘱审核, 糖尿病, 尿路感染, 抗菌药物, 合理用药, 临床药师

Abstract: AIM: To discuss the effects of examining prescriptions on rational application of antibiotics in diabetes patients combined with urinary tract infection.METHODS: 139 cases of patients with diabetes combined with urinary tract infection were collected in Department of endocrinology from June 2012-May 2014. And then the cases were divided into control group and experimental group according to whether the clinical pharmacists intervention. The pathogen distribution, drug resistance of bacterial, and the rationality of antimicrobial usage of two groups were comparatively analyzed.RESULTS: E. coli and enterococcus were more common detected by urine culture. Resistance of bacterial of ampicillin and levofloxacin were high. The dug resistance of gram-negative bacteria to ampicillin- sulbactam in experimental group was higher than that in the control group (P<0.05),while the dug resistance of gram positive bacteria to azithromycin in experimental group was lower than that in the control group (P<0.01). The number of cases of rational use of antimicrobial drugs in experimental group was significantly increased than that in the control group(P<0.05). The number of cases of not collecting urine culture, no adjustment of antimicrobial agents according to drug sensitive test, inadequate treatment and no combination indications in experimental group was significantly decreased than those in the control group (P<0.05).CONCLUSION: Clinical pharmacists promote the rational use of antimicrobial agents of diabetic patients with urinary tract infection by examining prescriptions.

Key words: examining prescription, diabetes mellitus, urinary tract infection, anti-bacterial agents, rational drug use, clinical pharmacist