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中国临床药理学与治疗学 ›› 2023, Vol. 28 ›› Issue (6): 705-713.doi: 10.12092/j.issn.1009-2501.2023.06.014

• 综述与讲座 • 上一篇    下一篇

丹参酮IIA治疗缺血性脑卒中后神经损伤的信号通路研究进展

秦文秀1，2，3，许军峰1，2，杨  婷1，2，3，王坪霏1，2，3   

  1. 1天津中医药大学第一附属医院，天津  300381；
    2国家中医针灸临床医学研究中心，天津  300381；
    3天津中医药大学，天津  301617
  • 收稿日期:2023-01-28 修回日期:2023-06-01 出版日期:2023-06-26 发布日期:2023-07-12
  • 通讯作者: 许军峰，女，博士，主任医师，研究方向：脑血管病及神经系统疾病。 E-mail：239498173@qq.com
  • 作者简介:秦文秀，女，硕士研究生，研究方向：脑血管病及神经系统疾病。 E-mail：1139705105@qq.com
  • 基金资助:
    天津中医药大学天津市教委科研计划项目（2022ZD045）

Research progress on signaling pathway of tanshinoneIIA in treatment of nerve injury after ischemic stroke

QIN Wenxiu1,2,3, XU Junfeng1,2, YANG Ting1,2,3, WANG Pingfei1,2,3   

  1. 1First Teaching Hospital of Tianjin University of T raditional Chinese Medicine, Tianjin 300381, China; 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China; 3Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • Received:2023-01-28 Revised:2023-06-01 Online:2023-06-26 Published:2023-07-12

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摘要：

丹参酮IIA是传统中药丹参发挥药理作用的主要活性成分之一，经现代研究证实具有抗缺血性脑卒中后神经损伤作用。本文通过检索文献，梳理近年来丹参酮IIA作用于缺血性脑卒中后神经损伤的信号通路及其作用机制，发现丹参酮IIA可通过调控PI3K/Akt/mTOR、Nrf2、NF-κB、NLRP3、MAPK等多条信号通路，抑制IL-6、IL-8、TNF-α等关键炎性因子的活性和释放、上调神经元特异性结构蛋白表达、抑制星形胶质细胞活化和增殖，发挥抗神经炎症、氧化应激、神经元凋亡等作用，从而减轻缺血性脑卒中后神经细胞的损伤，显示出多靶点、多途径、多层次和交互性的机制特点。基于此，本文对丹参酮IIA干预上述信号通路对缺血性脑卒中后的神经保护机制进行了简要综述，以期为丹参酮IIA的临床应用和药物研发提供参考。

关键词: 丹参酮IIA, 中药, 缺血性脑卒中, 神经, 信号通路

Abstract:

Tanshinone IIA is one of the main active components of traditional Chinese medicine Salvia miltiorrhiza, which plays a pharmacological role, and has been proved by modern research to have the effect of anti ischemic stroke nerve damage. This article reviews the signal pathway and mechanism of tanshinone IIA on nerve damage after ischemic stroke in recent years through literature search, and finds that tanshinone IIA can regulate the activity and release of PI3K/Akt/mTOR, Nrf2, NF-κB. NLRP3, MAPK and other signal pathways, inhibit IL-6, IL-8 and TNF-α, up regulate the expression of neuron specific structural proteins, inhibit the activation and proliferation of astrocytes, play the role of anti neuroinflammation, oxidative stress, neuronal apoptosis, etc., thus reducing the damage of neurons after ischemic stroke, showing the mechanism characteristics of multi target, multi-channel and multi-level interaction. Based on this, this article briefly reviewed the neuroprotective mechanism of tanshinone IIA intervention on the above signal pathways after ischemic stroke, in order to provide reference for the clinical application and drug development of tanshinone IIA.

Key words: tanshinone IIA, traditional Chinese medicine, ischemic stroke, nerve, signaling pathway

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