利拉鲁肽治疗后2型糖尿病合并冠心病患者肠道菌群变化及其与糖、脂代谢指标相关性

doi:10.12092/j.issn.1009-2501.2025.08.009

中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (8): 1084-1091.doi: 10.12092/j.issn.1009-2501.2025.08.009

利拉鲁肽治疗后2型糖尿病合并冠心病患者肠道菌群变化及其与糖、脂代谢指标相关性

邢英, 郑嵘炅, 姜春晖, 玛依拉·卡哈尔, 木胡牙提·乌拉斯汉

新疆医科大学第一附属医院综合内四科,乌鲁木齐 830000,新疆

收稿日期:2024-08-01 修回日期:2024-10-21 出版日期:2025-08-26 发布日期:2025-08-12
通讯作者: 木胡牙提·乌拉斯汉,男,博士,教授,博导,主任医师,从事心血管基础与临床研究。E-mail： muhuyati@163.com
作者简介:邢英,女,博士研究生,副主任医师,从事糖尿病基础和临床相关研究。E-mail： 86143807@qq.com
基金资助:
2025年度自治区卫生健康保健科研专项项目（BL202518）

Changes of intestinal flora in patients with type 2 diabetes mellitus complicated with coronary heart disease after liraglutide treatment and its correlation with glucose and lipid metabolism indexes

XING Ying, ZHENG Rongjiong, JIANG Chunhui, Mayila·kahaer, Muhuyati·wulasihan

Department of Endocrinology, Xinjiang Medical University First Affiliated Hospital, Urumqi 830000, Xinjiang, China

Received:2024-08-01 Revised:2024-10-21 Online:2025-08-26 Published:2025-08-12

摘要/Abstract

摘要： 目的：探究利拉鲁肽治疗后2型糖尿病合并冠心病患者肠道菌群变化特征及其与糖、脂代谢指标相关性。方法：选取2019年6月至2022年3月新疆医科大学第一附属医院收治的2型糖尿病合并冠心病患者26例,比较利拉鲁肽治疗前后患者糖、脂代谢指标以及肠道菌群（高通量测序技术）的变化,并分析糖、脂代谢指标与肠道菌群的相关性。结果：与治疗前相比,患者的糖代谢指标和脂代谢指标均呈显著降低的变化趋势（P<0.01）;利拉鲁肽对肠道菌群多样性无显著影响（P>0.05）,但能够显著改变肠道菌群组成（P<0.05）;在毛螺菌科等有益菌显著增加的同时,显著降低埃希氏杆菌属等致病菌丰度（P<0.05）,促进短链脂肪酸生成及机体代谢。结论：利拉鲁肽能够影响2型糖尿病合并冠心病患者肠道菌群组成进而参与调节糖、脂代谢过程。

关键词: 2型糖尿病, 冠心病, 肠道菌群, 利拉鲁肽

Abstract: AIM: To explore the changes of intestinal flora in patients with type 2 diabetes mellitus complicated with coronary heart disease after liraglutide treatment and its correlation with glucose and lipid metabolism indexes. METHODS: Twenty-six patients with type 2 diabetes mellitus complicated with coronary heart disease were selected to compare the changes of glucose and lipid metabolism indexes and intestinal flora (high-throughput sequencing technique) before and after liraglutide treatment, and to analyze the correlation between glucose and lipid metabolism indexes and intestinal flora. RESULTS: Compared with those before treatment, the indexes of glucose metabolism and lipid metabolism in the patients were significantly decreased (P<0.01). Liraglutide had no significant effect on the diversity of intestinal flora (P>0.05), but can significantly change the composition of intestinal flora (P<0.05). While beneficial bacteria such as Lachnospiraceae increased significantly, it significantly reduced the abundance of pathogenic bacteria such as Escherichia_Shigella (P<0.05), and promoted the production of short-chain fatty acids and body metabolism. CONCLUSION: Lilalutide can affect the composition of intestinal flora in type 2 diabetes patients with coronary heart disease, and then participate in the regulation of glucose and lipid metabolism.

Key words: type 2 diabetes, coronary heart disease, intestinal flora, liraglutide

中图分类号:

R587.1

邢英, 郑嵘炅, 姜春晖, 玛依拉·卡哈尔, 木胡牙提·乌拉斯汉. 利拉鲁肽治疗后2型糖尿病合并冠心病患者肠道菌群变化及其与糖、脂代谢指标相关性[J]. 中国临床药理学与治疗学, 2025, 30(8): 1084-1091.

XING Ying, ZHENG Rongjiong, JIANG Chunhui, Mayila·kahaer, Muhuyati·wulasihan. Changes of intestinal flora in patients with type 2 diabetes mellitus complicated with coronary heart disease after liraglutide treatment and its correlation with glucose and lipid metabolism indexes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2025, 30(8): 1084-1091.

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利拉鲁肽治疗后2型糖尿病合并冠心病患者肠道菌群变化及其与糖、脂代谢指标相关性

Changes of intestinal flora in patients with type 2 diabetes mellitus complicated with coronary heart disease after liraglutide treatment and its correlation with glucose and lipid metabolism indexes

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