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中国临床药理学与治疗学 ›› 2009, Vol. 14 ›› Issue (4): 426-431.

• 临床药理学 • 上一篇    下一篇

中国汉族人三磷酸肌苷焦磷酸酶活性的分布

李维亮, 辛华雯, 吴笑春, 李罄, 熊磊   

  1. 广州军区武汉总医院临床药理科, 武汉430070, 湖北
  • 收稿日期:2008-11-21 修回日期:2009-03-17 发布日期:2020-10-29
  • 通讯作者: 辛华雯,女,主任医师,主要从事临床药理研究。Tel:027-68878690 E-mail:huawenxin@163.com
  • 作者简介:李维亮,女,药师,主要从事临床药理研究。Tel:027-68878689 E-mail:liweiliango@sohu.com
  • 基金资助:
    全军科学技术研究“十一五”计划课题(06MA131)

Distribution of inosine triphosphate pyrophosphohydrolase activity in Han Chinese

LI Wei-liang, XING Hua-wen, WU Xiao-chun, LI Qing, XIONG Lei   

  1. Department of Clinical Pharmacology, Wuhan General Hospital of Guangzhou Command, Wuhan 430070, Hubei, China
  • Received:2008-11-21 Revised:2009-03-17 Published:2020-10-29

摘要: 目的: 研究三磷酸肌苷焦磷酸酶(ITPA)活性在中国汉族人中的分布。方法: 运用HPLC 法测定402 名健康汉族人红细胞的ITPA 活性。结果: 不同性别、不同血型汉族人的红细胞ITPA 活性均值差异无统计学意义(P>0.05),其ITPA 活性呈双峰分布,活性缺乏率为27.6 %。此外发现6 例ITPA 活性缺乏者,占研究总人数的1.47 %。结论: 中国汉族人红细胞ITPA 活性呈双峰分布。

关键词: 三磷酸肌苷焦磷酸酶, 汉族, 活性

Abstract: AIM: To study the distribution of inosine triphosphate pyrophosphatase (ITPA) activity in Han Chinese.METHODS: The erythrocyte ITPA activity was detected in healthy Han Chinese by HPLC assay (n=402).RESULTS: There was no significant difference in the mean ITPA activity between male and female of Han Chinese or among different blood types(P>0.05) , a bimodal distribution of ITPA activity was found and the frequency of the ITPA deficiency was 27.6 % in Han Chinese.Furthermore, 6cases with ITPA activity deficiency were found, accounting for 1.47 % of total healthy recipients.CONCLUSION: The distribution of erythrocyte ITPA activity shows a bimodal distribution in Han Chinese.

Key words: inosine triphosphate pyrophosphatase, Han Chinese, activity

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