AIM: To compare the therapeutic effects of rats with facial nerve injury in different dosage forms of Qianzheng Powder and explore its optimal treatment. METHODS: The 60 SD rats were randomly divided into model group, powder group, decoction group with 18 rats in each group and 6 control groups. In addition to the control group, the remaining 3 groups were rat models with vascular clamping of the closed facial nerve causing facial nerve damage. The powder group was given by Qianzheng powder and rice wine to mix well. The decoction group was given 2 mL of Qianzheng Powder decoction for gastric filling (Qianzheng Powder 2 430 mg·kg-1·d-1）. Once a day for 14 consecutive days, followed by normal feeding for 7 days. The control and model groups were fed normally for 21 days. Behavioral scoring, neuroelectrophysiology detection, and facial nerve tissue were observed on the rats of each module at 7 days, 14 days, and 21 days, respectively. RESULTS: Behavioral score comparison: The 14th postoperative powder group and decoction group scored lower than the model group (P<0.05). Comparison of facial nerve electrophysiological tests: The 14th postoperative, compared with model group, CMAP latency in both decoction group and powder group was decreased (P<0.05), while the latency of powder group was faster (P<0.01). At 21st postoperative, the amplitude of CMAP in the powder group was significantly higher than that in the decoction group.Histological observations show: In the 7th day after surgery, the model group, the powder group, and the decoction group all showed atrophy of the neural basement membrane, a large number of cell vacuole degeneration and inflammatory cell infiltration. 14 days after surgery, the model group still had nerve bundle atrophy; In the powder group and decoction group, the tissue structure of the neural basement membrane was partially restored, the nerve bundle membrane was partially visible, the cell swelling had subsided, and some cell vacuole degeneration could still be seen. 21 days after surgery, the atrophy of the basal membrane of the model group was restored, and the nerve structure part showed that some cells still had vacuolar degeneration; In the powder group and decoction group, the neural tissue structure was restored, the cells were arranged in an orderly manner, and the swelling and degeneration were significantly reduced. However, a small amount of angioplasia and nerve cell hyperplasia could be seen in the powder group. In the control group, the structure of each layer of the tissue was clear, the cells were arranged in an orderly manner, and there was no obvious positive expression. CONCLUSION: The Qianzheng powder have a significant effect on rats with facial nerve injury. The powder can better promote the recovery of facial nerve electrophysiology and tissue structure in rats with facial nerve injury, and has good safety.