Advances in studies of neurotoxicity of angiotensin(1-7)

doi:10.12092/j.issn.1009-2501.2018.12.019

Abstract

Abstract:

Angiotensin (1-7) reverse regulation of the classic ACE-AngII-AT axis through the branch of the new role of angiotensin converting enzyme ACE2-Ang (1-7) -Mas receptor axis. Ang (1-7) is widely distributed in the supraoptic and paraventricular nucleus of hypothalamus. It has effects of dilating blood vessels, anti-arrhythmia, anti-inflammatory and so on, which could protect the cardiovascular and central nervous system by affecting the synthesis and releasing other central neurotransmitters through bradykinin, nitric oxide synthase (NOS), cyclooxygenase (COX) and some signaling pathways. This paper reviews the distribution of Ang (1-7) and the diversity of the biological functions in the central nervous system.

Key words: angiotensin(1-7), renin-angiotensin system, reverse regulation, central nervous system

CLC Number:

CHEN Dan, GUO Yujin, YANG Mengqi, CA Hualin, JIANG Pei. Advances in studies of neurotoxicity of angiotensin(1-7)[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(12): 1425-1430.

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