Short-chain fatty acids as signal molecules in intestinal inflammation

doi:10.12092/j.issn.1009-2501.2019.11.013

Abstract

Abstract:

The intestinal microbial metabolites short-chain fatty acids（SCFA）act as both extracellular and intracellular signaling molecules to against inflammation. Outside of the cell, they function as agonists for several GPCRs. Inside the cell, SCFA inhibit HDACs. This review mainly discussed the source, composition, synthesis, distribution of SCFA, the effects and the potential molecular mechanisms of SCFA that affecting intestinal inflammation.

Key words: short-chain fatty acids, HDACI, GPCRs, intestinal, inflammation

CLC Number:

R969
R516

HUANG Xinyi, GUO Fei, ZENG Xiangchang, OUYANG Dongsheng. Short-chain fatty acids as signal molecules in intestinal inflammation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(11): 1293-1299.

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