Research progress of endoplasmic reticulum stress in heart diseases

doi:10.12092/j.issn.1009-2501.2019.11.016

Abstract

Abstract:

Endoplasmic reticulum is an important organelle for intracellular protein processing and modification.It produces a series of reactions, including unfolded protein reactions, to maintain intracellular homeostasis and protein quality control.The accumulation of unfolded or misfolded proteins in endoplasmic reticulum will further lead to endoplasmic reticulum stress and cell and organism dysfunction.Recent studies have found that endoplasmic reticulum stress is highly related to the occurrence and development of various heart diseases.This article reviews the role of endoplasmic reticulum stress in the occurrence and development of ischemic heart disease,primary cardiomyopathy,myocardial hypertrophy and heart failure.Based on the mechanism of endoplasmic reticulum stress in cardiac diseases,it can provide theoretical basis and application means for the treatment of cardiac diseases by targeting endoplasmic reticulum stress.

Key words: endoplasmic reticulum stress, heart diseases, targeting

CLC Number:

R541

WANG Kaiyang, LI Xiaoli, CAI Yongqing. Research progress of endoplasmic reticulum stress in heart diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(11): 1310-1314.

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