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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2022, Vol. 27 ›› Issue (3): 328-333.doi: 10.12092/j.issn.1009-2501.2022.03.013

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Research progress on bone metabolism disorders associated with PCOS elucidated from endocrine hormones

DU Chen1,2, TIAN He3, CAO Yang1, WANG Yongjun2, ZHANG Yan2   

  1. 1Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; 2Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; 3Shenzhen Pingle Orthopaedic Hospital, Shenzhen 518118, Guangdong, China
  • Received:2022-02-07 Revised:2022-03-01 Online:2022-03-26 Published:2022-04-11

Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disease of women. Clinical studies have shown that PCOS patients are likely having abnormal bone metabolism, and with increased risk of osteoporosis. This review summarized the common pathological mechanisms for both PCOS and osteoporosis, and elucidated the research progress on PCOS-inducing bone metabolism disorders from emphasizing on the regulation of endocrine hormones including insulin, androgen, growth hormone, vitamin D, parathyroid hormone and calcitonin. It is expected that this review will shed new light on monitoring and intervention for bon health of PCOS patients.

Key words: polycystic ovary syndrome, endocrine, bone metabolism, osteoporosis, hormone

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