AIM: To study the improvement effect and possible mechanism of Shufeng Jiedu capsules(SFJDC) on viral pneumonia. METHODS: Forty-eight BALB/c mice were used to establish a viral pneumonia model by intranasal administration of influenza A virus H1N1. They were randomly divided into 4 groups, with twelve mice in each group. Except for the Model group, the treatment group was given oseltamivir (OSTW) , low and high dose groups of Shufeng Jiedu capsules (SFJDC-L,SFJD-H) by gavage,take another 12 mice as the normal group, continuously administered for 7 days. The physical signs of each group of mice were observed during the administration process, and the daily body weight change rate and disease activity index was calculated; After administration, lung, intestinal tissue, and intestinal contents were taken, and the pathological changes in mouse lung tissue were detected using hematoxylin eosin (HE) staining method, Alisin blue staining was used to detect goblet cells in the intestinal wall; RT-qPCR method for detecting viral load influenza (infA) and the expression of tumor necrosis factor-a (TNF-α) and interleukin-6 (IL-6) mRNA in mouse lung tissue; Detection of mouse gut microbiota using 16S rRNA high-throughput sequencing; ELISA method for detecting lipopolysaccharide (LPS) , TNF-α and IL-6 level in mouse serum; The expression of cyclic GMP AMP synthase (cGAS), interferon gene stimulating protein (STING), phospho-STING (p-STING), nuclear factor-κB (NF-κB) phospho-nuclear factor-κB (p-NF-κB) in lung tissue and ZO-1,Occludin in small small intestine was detected by Western Blotting. RESULTS: Compared with the model group, the lung index and viral load of mice in the Shufeng Jiedu capsules group were significantly reduced (P<0.01); significant reduction in lung tissue inflammation accompanied by TNF-α; The expression level of IL-6 mRNA decreased (P<0.01); The abundance of Firmicutes and Lachnospiraceae in the intestine significantly increased (P<0.01), while the abundance of Bacteroidetes and Bacteroidaceae communities significantly decreased (P<0.05 or 0.01); The number of goblet cells in the small intestine epithelium significantly increased (P<0.01); the levels of serum LPS and TNF-α,IL-6 were significantly reduced (P<0.01); The protein expression level of cGAS, p-STING, p-NF-κB significantly decreased in lung tissue (P<0.05 or 0.01), ZO-1, Occludin significantly decreased in small intestine (P<0.05). CONCLUSION: Shufeng Jiedu capsules reduces the inflammatory response of mice lung tissue, and its mechanism may be related to its regulation of intestinal flora, protection of intestinal mucosal barrier, and reduction the activation of cGAS/STING/NF-κB signaling pathway actived by LPS leakaging from the intestine.