Potential role and therapeutic prospects of glycolysis-lactylation modification in asthma

doi:10.12092/j.issn.1009-2501.2026.01.011

Abstract

Abstract:

Asthma is a heterogeneous disease characterized by chronic airway inflammation, airway hyperresponsiveness, and remodeling. Its pathological mechanisms involve complex interactions between multiple immune and structural cells. Recent studies reveal that glycolysis is closely associated with the pathogenesis and severity of asthma. Dysregulated glycolytic metabolism in various immune cells promotes asthmatic pathogenesis by inducing dysfunctions in both innate and adaptive immune responses. Lactate, the end-product of glycolysis, directly mediates lactylation modifications that regulate epigenetic processes and signaling pathways. This mechanism plays critical roles in Th2 inflammation, macrophage activation, and airway remodeling, potentially serving as a regulatory hub in asthma pathology. In this review, we discuss the potential roles and mechanisms of glycolysis-lactylation in asthma, analyze the feasibility of targeting the glycolysis-lactylation axis as a novel therapeutic approach for asthma, and provide references and directions for future research.

Key words: bronchial asthma, chronic airway inflammation, glycolysis, lactylation, metabolic reprogramming

CLC Number:

R562.2

Xiaoping SHEN, Dong WU, Lili YU, Bin WU. Potential role and therapeutic prospects of glycolysis-lactylation modification in asthma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(1): 96-106.

Figures/Tables 3

Fig.1 Mechanism of glycolysis-lactate metabolism and lactylation in cells GLUT: glucose transporter; MCT: monocarboxylate transporter; LDH: lactate dehydrogenase; MGO: methylglyoxal; LGSH: S-D-lactoylglutathione; GLO1: glyoxalase 1; KAT: lysine acetyltransferase. This diagram was created using BioGDP.com.

Fig.2 Regulatory mechanism of glycolysis-lactation in immune cells This figure was created using the Created with BioGDP.com.

Table 1 Targeted therapeutics for glycolysis-lactylation

Target	Drug	References
LDHA	FX11, Oxalate, GSK2837808A	[81-83]
HK2	Bergenin, 3-BP, 2-Deoxy-D-glucose (2-DG)	[85,93]
PFKFB3	3PO	[86-87,94]
MCT	Phloretin, Quercetin, BAY-8002, 7ACC, AR-C155858, AZD3965, CHC, Syrosingopine	[87-88]
P300	A-485	[92]

References 97

1	Asher MI, García-Marcos L, Pearce NE, et al. Trends in worldwide asthma prevalence[J]. Eur Respir J, 2020, 56 (6): 2002094. doi: 10.1183/13993003.02094-2020
2	Porsbjerg C, Melén E, Lehtimäki L, et al. Asthma[J]. Lancet (london, England), 2023, 401 (10379): 858- 873. doi: 10.1016/S0140-6736(22)02125-0
3	Asher MI, Rutter CE, Bissell K, et al. Worldwide trends in the burden of asthma symptoms in school-aged children: global asthma network phase I cross-sectional study[J]. Lancet (london, England), 2021, 398 (10311): 1569- 1580. doi: 10.1016/S0140-6736(21)01450-1
4	Yu J, Xu L, Han A, et al. The epidemiology of asthma in mainland china: a systematic review and meta-analysis[J]. BMC Public Health, 2024, 24 (1): 2888. doi: 10.1186/s12889-024-20330-1
5	Yuan L, Tao J, Wang J, et al. Global, regional, national burden of asthma from 1990 to 2021, with projections of incidence to 2050: a systematic analysis of the global burden of disease study 2021[J]. Eclinicalmedicine, 2025, 80, 103051. doi: 10.1016/j.eclinm.2024.103051
6	Qin Z, Chen Y, Wang Y, et al. Immunometabolism in the pathogenesis of asthma[J]. Immunology, 2024, 171 (1): 1- 17. doi: 10.1111/imm.13688
7	Li X, Qi S, Jiang Y, et al. Identification and validation of PARK7 as a novel mitochondria-related signature associated with immune microenvironment in asthma[J]. Int Immunopharmacol, 2025, 157, 114750. doi: 10.1016/j.intimp.2025.114750
8	Almeida L, Dhillon-LaBrooy A, Carriche G, et al. CD4 T-cell differentiation and function: unifying glycolysis, fatty acid oxidation, polyamines NAD⁺ mitochondria[J]. J Allergy Clin Immunol, 2021, 148 (1): 16- 32.
9	Liu S, Liao S, Liang L, et al. The relationship between CD4⁺ T cell glycolysis and their functions[J]. Trends Endocrinol Metab, 2023, 34 (6): 345- 360. doi: 10.1016/j.tem.2023.03.006
10	Alladina J, Smith NP, Kooistra T, et al. A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma [J]. Sci Immunol, 2023, 8(83): eabq6352.
11	Noe JT, Rendon BE, Geller AE, et al. Lactate supports a metabolic-epigenetic link in macrophage polarization [J]. Sci Adv, 2021, 7(46): eabi8602.
12	Zhang D, Tang Z, Huang H, et al. Metabolic regulation of gene expression by histone lactylation[J]. Nature, 2019, 574 (7779): 575- 580. doi: 10.1038/s41586-019-1678-1
13	Wang W, Zheng F, Lin C, et al. Changes in energy metabolism and macrophage polarization: Potential mechanisms of arsenic-induced lung injury[J]. Ecotoxicol Environ Saf, 2020, 204, 110948. doi: 10.1016/j.ecoenv.2020.110948
14	Antus B, Barta I, Kullmann T, et al. Assessment of exhaled breath condensate pH in exacerbations of asthma and chronic obstructive pulmonary disease: a longitudinal study[J]. Am J Respir Crit Care Med, 2010, 182 (12): 1492- 1497. doi: 10.1164/rccm.201003-0451OC
15	Ostroukhova M, Goplen N, Karim MZ, et al. The role of low-level lactate production in airway inflammation in asthma[J]. Am J Physiol Lung Cell Mol Physiol, 2012, 302 (3): L300- 307. doi: 10.1152/ajplung.00221.2011
16	Yang JQ, Kalim KW, Li Y, et al. RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation [J]. J Allergy Clin Immunol, 2016, 137(1): 231-245. e4.
17	Shan L, Chen L, Shen W, et al. FOXK2 facilitates the airway remodeling during chronic asthma by promoting glycolysis in a SIRT2-dependent manner[J]. FASEB J, 2024, 38 (13): e23756. doi: 10.1096/fj.202302284R
18	Li H, Sun L, Gao P, et al. Lactylation in cancer: current understanding and challenges[J]. Cancer Cell, 2024, 42 (11): 1803- 1807. doi: 10.1016/j.ccell.2024.09.006
19	Zhang X, Liu Y, Rekowski MJ, et al. Lactylation of tau in human alzheimer’s disease brains[J]. Alzheimers Dement, 2025, 21 (2): e14481.
20	Wan L, Zhang H, Liu J, et al. Lactylation and human disease[J]. Expert Rev Mol Med, 2025, 27, e10. doi: 10.1017/erm.2025.3
21	Hu Y, He Z, Li Z, et al. Lactylation: the novel histone modification influence on gene expression, protein function, and disease[J]. Clin Epigenet, 2024, 16 (1): 72. doi: 10.1186/s13148-024-01682-2
22	Schütterle DM, Hegner R, Temovska M, et al. Exclusive D-lactate-isomer production during a reactor-microbiome conversion of lactose-rich waste by controlling pH and temperature[J]. Water Res, 2024, 250, 121045. doi: 10.1016/j.watres.2023.121045
23	Rabinowitz JD, Enerback S. Lactate: The ugly duckling of energy metabolism[J]. Nat Metab, 2020, 2 (7): 566- 571. doi: 10.1038/s42255-020-0243-4
24	Yu C, Huang W, Zhou Z, et al. Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin[J]. Respir Res, 2022, 23 (1): 75. doi: 10.1186/s12931-022-01979-x
25	DeBerardinis RJ, Mancuso A, Daikhin E, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis[J]. Proc Natl Acad Sci USA, 2007, 104 (49): 19345- 19350. doi: 10.1073/pnas.0709747104
26	Soeters PB, Shenkin A, Sobotka L, et al. The anabolic role of the warburg, cori-cycle and crabtree effects in health and disease[J]. Clin Nutr, 2021, 40 (5): 2988- 2998. doi: 10.1016/j.clnu.2021.02.012
27	Pinheiro C, Longatto-Filho A, Azevedo-Silva J, et al. Role of monocarboxylate transporters in human cancers: state of the art[J]. J Bioenerg Biomembr, 2012, 44 (1): 127- 139. doi: 10.1007/s10863-012-9428-1
28	Pucino V, Cucchi D, Mauro C. Lactate transporters as therapeutic targets in cancer and inflammatory diseases[J]. Expert Opin Ther Targets, 2018, 22 (9): 735- 743. doi: 10.1080/14728222.2018.1511706
29	Halestrap AP, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond[J]. Pflugers Arch, 2004, 447 (5): 619- 628. doi: 10.1007/s00424-003-1067-2
30	Yang K, Fan M, Wang X, et al. Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis[J]. Cell Death Differ, 2022, 29 (1): 133- 146. doi: 10.1038/s41418-021-00841-9
31	Yang YH, Wang QC, Kong J, et al. Global profiling of lysine lactylation in human lungs[J]. Proteomics, 2023, 23 (15): 2200437. doi: 10.1002/pmic.202200437
32	Zhu R, Ye X, Lu X, et al. ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion [J]. Cell Metab, 2025, 37(2): 361-376. e7.
33	Lu Z, Fang P, Li S, et al. Lactylation of histone H3k18 and Egr1 promotes endothelial glycocalyx degradation in sepsis‐induced acute lung injury[J]. Adv Sci, 2024, 12 (7): 2407064. doi: 10.1002/advs.202407064
34	Niu Z, Chen C, Wang S, et al. HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription[J]. Nat Commun, 2024, 15, 3561. doi: 10.1038/s41467-024-47900-6
35	Gaffney DO, Jennings EQ, Anderson CC, et al. Non-enzymatic lysine lactoylation of glycolytic enzymes [J]. Cell Chem Biol, 2020, 27(2): 206-213. e6.
36	Pucino V, Certo M, Bulusu V, et al. Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4+ T cell metabolic rewiring[J]. Cell Metab, 2019, 30 (6): 1055- 1074. doi: 10.1016/j.cmet.2019.10.004
37	孔春雪, 刘其器, 张立伟, 等. 孟鲁司特钠通过PHD2/HIF-1α通路抑制哮喘小鼠气道炎症反应[J]. 实用医学杂志, 2025, 41 (5): 664- 669. doi: 10.3969/j.issn.1006-5725.2025.05.007
38	Ho WE, Xu YJ, Xu F, et al. Metabolomics reveals altered metabolic pathways in experimental asthma[J]. Am J Respir Cell Mol Biol, 2013, 48 (2): 204- 211. doi: 10.1165/rcmb.2012-0246OC
39	Manuel AM, van de Wetering C, MacPherson M, et al. Dysregulation of pyruvate kinase M2 promotes inflammation in a mouse model of obese allergic asthma[J]. Am J Respir Cell Mol Biol, 2021, 64 (6): 709- 721. doi: 10.1165/rcmb.2020-0512OC
40	van de Wetering C, Manuel AM, Sharafi M, et al. Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2[J]. Redox Biol, 2021, 47, 102160. doi: 10.1016/j.redox.2021.102160
41	Lv X, Wang W, Dong H, et al. Glycolysis in asthma: its role and potential as a diagnostic or therapeutic target[J]. Int Immunopharmacol, 2025, 148, 114143. doi: 10.1016/j.intimp.2025.114143
42	Ivanova O, Richards LB, Vijverberg SJ, et al. What did we learn from multiple omics studies in asthma?[J]. Allergy, 2019, 74 (11): 2129- 2145. doi: 10.1111/all.13833
43	Boonpiyathad T, Sozener ZC, Satitsuksanoa P, et al. Immunologic mechanisms in asthma[J]. Semin Immunol, 2019, 46, 101333. doi: 10.1016/j.smim.2019.101333
44	Hudey SN, Ledford DK, Cardet JC. Mechanisms of non-type 2 asthma[J]. Curr Opin Immunol, 2020, 66, 123- 128. doi: 10.1016/j.coi.2020.10.002
45	Dorscheid D, Gauvreau GM, Georas SN, et al. Airway epithelial cells as drivers of severe asthma pathogenesis[J]. Mucosal Immunol, 2025, 18 (3): 524- 536. doi: 10.1016/j.mucimm.2025.03.003
46	Porsbjerg CM, Sverrild A, Lloyd CM, et al. Anti-alarmins in asthma: targeting the airway epithelium with next-generation biologics[J]. Eur Respir J, 2020, 56 (5): 2000260. doi: 10.1183/13993003.00260-2020
47	Hammad H, Lambrecht BN. The basic immunology of asthma[J]. Cell, 2021, 184 (9): 2521- 2522.
48	Bryant N, Muehling LM. T-cell responses in asthma exacerbations[J]. Ann Allergy Asthma Immunol, 2022, 129 (6): 709- 718. doi: 10.1016/j.anai.2022.07.027
49	Wu H, Huang H, Zhao Y. Interplay between metabolic reprogramming and post-translational modifications: from glycolysis to lactylation[J]. Front Immunol, 2023, 14, 1211221. doi: 10.3389/fimmu.2023.1211221
50	Chen X, Lin H, Yang D, et al. Early-life undernutrition reprograms CD4(+) T-cell glycolysis and epigenetics to facilitate asthma[J]. J Allergy Clin Immunol, 2019, 143 (6): 2038- 2051. doi: 10.1016/j.jaci.2018.12.999
51	Matheson MC, DOA, Burgess JA, et al. Preterm birth and low birth weight continue to increase the risk of asthma from age 7 to 43[J]. J Asthma, 2017, 54 (6): 616- 623. doi: 10.1080/02770903.2016.1249284
52	Canoy D, Pekkanen J, Elliott P, et al. Early growth and adult respiratory function in men and women followed from the fetal period to adulthood[J]. Thorax, 2007, 62 (5): 396- 402. doi: 10.1136/thx.2006.066241
53	Lopez KA, Nehring HP, Krause FF, et al. Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells[J]. EMBO Rep, 2022, 23 (12): e54685.
54	Thio CLP, Chang YJ. The modulation of pulmonary group 2 innate lymphoid cell function in asthma: from inflammatory mediators to environmental and metabolic factors[J]. Exp Mol Med, 2023, 55 (9): 1872- 1884. doi: 10.1038/s12276-023-01021-0
55	Zhang X, Liu J, Li X, et al. Blocking the HIF-1α/glycolysis axis inhibits allergic airway inflammation by reducing ILC2 metabolism and function[J]. Allergy, 2025, 80 (5): 1309- 1334. doi: 10.1111/all.16361
56	Helou DG, Shafiei-Jahani P, Lo R, et al. PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity[J]. Nat Commun, 2020, 11, 3998. doi: 10.1038/s41467-020-17813-1
57	Jones N, Vincent EE, Felix LC, et al. Interleukin-5 drives glycolysis and reactive oxygen species-dependent citric acid cycling by eosinophils[J]. Allergy, 2020, 75 (6): 1361- 1370.
58	Kottyan LC, Collier AR, Cao KH, et al. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner[J]. Blood, 2009, 114 (13): 2774- 2782. doi: 10.1182/blood-2009-05-220681
59	Huang W, Zhang Y, Li Y, et al. Vitamin D impedes eosinophil chemotaxis via inhibiting glycolysis-induced CCL26 expression in eosinophilic chronic rhinosinusitis with nasal polyps[J]. Cell Commun Signal, 2025, 23 (1): 104. doi: 10.1186/s12964-025-02078-2
60	Weiss ST, Mirzakhani H, Carey VJ, et al. Prenatal vitamin D supplementation to prevent childhood asthma: 15-year results from the vitamin D antenatal asthma reduction trial (VDAART)[J]. J Allergy Clin Immunol, 2024, 153 (2): 378- 388. doi: 10.1016/j.jaci.2023.10.003
61	Gan PXL, Liao W, Lim HF, et al. Dexamethasone protects against aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism[J]. Pharmacol Res, 2023, 196, 106929. doi: 10.1016/j.phrs.2023.106929
62	Cai Y, Sugimoto C, Arainga M, et al. In vivo characterization of alveolar and interstitial lung macrophages in rhesus macaques: implications for understanding lung disease in humans[J]. J Immunol, 2014, 192 (6): 2821- 2829. doi: 10.4049/jimmunol.1302269
63	Zhang K, Guo J, Yan W, et al. Macrophage polarization in inflammatory bowel disease[J]. Cell Commun Signal, 2023, 21 (1): 367. doi: 10.1186/s12964-023-01386-9
64	Robbe P, Draijer C, Borg TR, et al. Distinct macrophage phenotypes in allergic and nonallergic lung inflammation[J]. Am J Physiol Lung Cell Mol Physiol, 2015, 308 (4): L358- 367. doi: 10.1152/ajplung.00341.2014
65	He L, Jhong JH, Chen Q, et al. Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors[J]. Cell Rep, 2021, 37 (5): 109955. doi: 10.1016/j.celrep.2021.109955
66	Zhao Q, Chu Z, Zhu L, et al. 2-deoxy-d-glucose treatment decreases anti-inflammatory M2 macrophage polarization in mice with tumor and allergic airway inflammation[J]. Front Immunol, 2017, 8, 637. doi: 10.3389/fimmu.2017.00637
67	Chen N, Xie QM, Song SM, et al. Dexamethasone protects against asthma via regulating hif-1α-glycolysis-lactate axis and protein lactylation[J]. Int Immunopharmacol, 2024, 131, 111791. doi: 10.1016/j.intimp.2024.111791
68	Li J, Zeng G, Zhang Z, et al. Urban airborne PM(2.5) induces pulmonary fibrosis through triggering glycolysis and subsequent modification of histone lactylation in macrophages[J]. Ecotoxicol Env Saf, 2024, 273, 116162. doi: 10.1016/j.ecoenv.2024.116162
69	Wang J, Yang P, Yu T, et al. Lactylation of PKM2 suppresses inflammatory metabolic adaptation in pro-inflammatory macrophages[J]. Int J Biol Sci, 2022, 18 (16): 6210- 6225. doi: 10.7150/ijbs.75434
70	Crisford H, Sapey E, Rogers GB, et al. Neutrophils in asthma: the good, the bad and the bacteria[J]. Thorax, 2021, 76 (8): 835- 844. doi: 10.1136/thoraxjnl-2020-215986
71	Moore WC, Hastie AT, Li X, et al. Sputum neutrophils are associated with more severe asthma phenotypes using cluster analysis[J]. J Allergy Clin Immunol, 2014, 133 (6): 1557- 1563.
72	De Volder J, Vereecke L, Joos G, et al. Targeting neutrophils in asthma: a therapeutic opportunity?[J]. Biochem Pharmacol, 2020, 182, 114292. doi: 10.1016/j.bcp.2020.114292
73	Gu W, Huang C, Chen G, et al. The role of extracellular traps released by neutrophils, eosinophils, and macrophages in asthma[J]. Respir Res, 2024, 25 (1): 290. doi: 10.1186/s12931-024-02923-x
74	Pulikkot S, Zhao M, Fan Z. Real-time measurement of the mitochondrial bioenergetic profile of neutrophils [J]. J Vis Exp Jove, 2023(196): 10.3791/64971.
75	Awasthi D, Nagarkoti S, Sadaf S, et al. Glycolysis dependent lactate formation in neutrophils: a metabolic link between NOX-dependent and independent NETosis[J]. Biochim Biophys Acta (BBA) - Mol Basis Dis, 2019, 1865 (12): 165542. doi: 10.1016/j.bbadis.2019.165542
76	Qiu CZ, Zhou R, Zhang HY, et al. Histone lactylation-ROS loop contributes to light exposure-exacerbated neutrophil recruitment in zebrafish[J]. Commun Biol, 2024, 7 (1): 887. doi: 10.1038/s42003-024-06543-5
77	Xie X, Wen C, Peng Q, et al. H3K9/18 lactylation regulates DNA damage due to nickel exposure in human bronchial epithelial cells[J]. Toxicol Appl Pharmacol, 2025, 499, 117347. doi: 10.1016/j.taap.2025.117347
78	Ma N, Wang L, Meng M, et al. D-sodium lactate promotes the activation of NF-κB signaling pathway induced by lipopolysaccharide via histone lactylation in bovine mammary epithelial cells[J]. Microb Pathog, 2025, 199, 107198. doi: 10.1016/j.micpath.2024.107198
79	Li K, Li M, Li W, et al. Airway epithelial regeneration requires autophagy and glucose metabolism[J]. Cell Death Dis, 2019, 10 (12): 875. doi: 10.1038/s41419-019-2111-2
80	Chen X, Liu L, Kang S, et al. The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation[J]. Sci Adv, 2023, 9 (12): eadd9554. doi: 10.1126/sciadv.add9554
81	Xu J, Li J, Yu Z, et al. HMGB1 promotes HLF-1 proliferation and ECM production through activating HIF1-α-regulated aerobic glycolysis[J]. Pulm Pharmacol Ther, 2017, 45, 136- 141. doi: 10.1016/j.pupt.2017.05.015
82	Wu D, Wang S, Wang F, et al. Lactate dehydrogenase a (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension[J]. J Transl Med, 2024, 22 (1): 738. doi: 10.1186/s12967-024-05543-7
83	Mi Y, Tang M, Wu Q, et al. NMAAP1 regulated macrophage polarizion into M1 type through glycolysis stimulated with BCG[J]. Int Immunopharmacol, 2024, 126, 111257. doi: 10.1016/j.intimp.2023.111257
84	Yuan Y, Fan G, Liu Y, et al. The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis[J]. Cell Mol Immunol, 2022, 19 (4): 504- 515. doi: 10.1038/s41423-021-00806-5
85	Ji X, Nie C, Yao Y, et al. S100A8/9 modulates perturbation and glycolysis of macrophages in allergic asthma mice[J]. PeerJ, 2024, 12, e17106. doi: 10.7717/peerj.17106
86	Gong Y, Lan H, Yu Z, et al. Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells[J]. Biochem Biophys Res Commun, 2017, 491 (2): 522- 529. doi: 10.1016/j.bbrc.2017.05.173
87	Telang S, Clem BF, Klarer AC, et al. Small molecule inhibition of 6-phosphofructo-2-kinase suppresses T cell activation[J]. J Transl Med, 2012, 10 (1): 95. doi: 10.1186/1479-5876-10-95
88	Felmlee MA, Jones RS, Rodriguez-Cruz V, et al. Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease[J]. Pharmacol Rev, 2020, 72 (2): 466- 485. doi: 10.1124/pr.119.018762
89	Shi S, Li JC, Zhou XY, et al. Transport mechanism and drug discovery of human monocarboxylate transporter 1[J]. Acta Pharmacol Sin, 2025, 46 (8): 2323- 2333. doi: 10.1038/s41401-025-01517-7
90	Cui H, Xie N, Banerjee S, et al. Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation[J]. Am J Respir Cell Mol Biol, 2021, 64 (1): 115- 125. doi: 10.1165/rcmb.2020-0360OC
91	Zong Z, Ren J, Yang B, et al. Emerging roles of lysine lactyltransferases and lactylation[J]. Nat Cell Biol, 2025, 27 (4): 563- 574. doi: 10.1038/s41556-025-01635-8
92	Liu S, He Y, Jin L, et al. H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells[J]. Toxicology, 2025, 514, 154109. doi: 10.1016/j.tox.2025.154109
93	Li X, Xie L, Zhou L, et al. Bergenin inhibits tumor growth and overcomes radioresistance by targeting aerobic glycolysis[J]. Am J Chin Med, 2023, 51 (7): 1905- 1925. doi: 10.1142/S0192415X23500842
94	Abdali A, Baci D, Damiani I, et al. In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3[J]. Pharmacol Res, 2021, 168, 105592. doi: 10.1016/j.phrs.2021.105592
95	Cui L, Yang Y, Hao Y, et al. Nanotechnology-based therapeutics for airway inflammatory diseases[J]. Clin Rev Allergy Immunol, 2025, 68 (1): 12. doi: 10.1007/s12016-024-09019-w
96	Wang X, Wang L, Hao Q, et al. Harnessing glucose metabolism with nanomedicine for cancer treatment[J]. Theranostics, 2024, 14 (17): 6831- 6882. doi: 10.7150/thno.100036
97	Jiang K, Liu H, Chen X, et al. Reprogramming of glucose metabolism by nanocarriers to improve cancer immunotherapy: recent advances and applications[J]. Int J Nanomed, 2025, 20, 4201- 4234. doi: 10.2147/ijn.s513207

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[10]	SHEN Ju-xin, QIN E, LI Ming-hui, SUN Jian,ZHOU Guo-zhong. Value of leukotrienes C4,8-isoprostane, nitrite/nitrate in exhaled breath condensate and the effect of montelukast on inflammatory factors in asthma [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(7): 802-805.
[11]	LV Xiao-hua, WU Tie, WANG Hui, QIN Dong-yun. Effect of liquorice on airway inflammation and Th₁/Th₂ imbalance in mouse model [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(5): 532-534.
[12]	YAO Yu-You, WU Qin-Si, YAO Hai-Yun. Clinical and experimental study of effects of kechuanningPowder on bronchial asthma [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(4): 438-440.
[13]	LI Yun-Quan, KONG Hai-Hong, LI Min-Hua. Effect of motilium on 50 cases of bronchial asthma associated with gastroe-sophageal reflux [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(3): 252-254.