Abstract: Aim To know whether the sex hormone played a role in formation of gallstone, the experimental study on the drugs was designed. Methods 60 rabbits were randomly divided into 6 groups in 4 of which(groups E₂,P,T,H) estradiol,progesterone,testosterone and HCG were administered separately, and normal saline and refined oil were given to as control in the other groups(C₁、C₂). The animals were put to death in 6 weeks. The blood, bite, gallbladder, bile duct, liver and gallstones were assayed. Results The gallstone formation rate was 90% in group E₂,50% in group H and 10% in group T. There no gallstone that was formed in the alimals in groups P, C₁ and C₂. Most of the gallstones were found in the female animals. Only in group E₂ were the gallstones found in 4 male rabbits. The comnpostion of stone was mainly choles-terol. Conclusion Among the sex hormones estradiol and HCG are in relation to the formation of gallbladder cholestrol stone.

Key words: Sex hormone, Gallbladder, Gallstone, Aetiolgy