Abstract: Aim To observe the therapeutic effects of polysaccharide sulfate. Methods Thirty - two patients with coronary heart disease ( M20, F12; age 58±10a) were treated with polysaccharide sulfate 200mg in 10% glucose solution 500ml, iv, drip, qd,for 14d as a courae. For the control group, 16 patients with coronary heart disease (M11, F5; age56±9a) were treated with injection of compound salvia miltiorrhiza 16ml in 10% glucose solution iv, drip, qd, for 14d. Results The efficacy for angina in the polysaccharide sulfate group was similar to that in the compound salvia miltiorrhiza group (90% to 88%), but the EKG, heart rate, pressure blood, blood fat, blood rheology and cardiac function were more significantly improved in the polysaccharide sulfate group than those in the compound salvia miltiorrhiza group(P<0.05). Conclusion Polysaccharide sulfate could have a good effect on the treatment of coronary heart disease.

Key words: Mucoplysaccharide, Coronary heart disease, Blood fat, Blood rheology, Cardiac function