Abstract: Aim This study aims mainly to explore the effectiveness and mechanism of Y uejiancao, a preparation abounding in linoleic acid (75%+) in the treatment of duodenal ulcer. Methods Yuejiancao (1.5g tid) was used respectively in 31 patients with dodenal ulcer and raniti-dine(0.15g,bid) in 32 matched control patients with the same disease for four weeks. The effectiveness of treament was obseverd by the examination of gastroendoscopy, and the values. of GMBF and PD were determined before and after treatment. Results A 87. 10% response. rate was acquired in Y uejiancao treated patients and a 87. 50% response rate in ranitidine group. There was no statistical difference between two groups. GMBF and PD increased significantly after treatment with Yuejiancao (P<0.05). Conclusion These findings sug-gest that Yuejiancao is an effective agent for treating peptic ulcerous disease. The effectire meckanism of Yuejiancao is mediated by significantly increasing GMBF and PD(P<0. 05).

Key words: Yuejiancao, linoleic acid, GMBF, PD, duodenal ulcer