Abstract: Aim and Methods In order to identify and analysis the effects of compound pseudoephedrine on cough reaction, wihch consist of pseudoephedrine, dext romethorphan and chlerpheni-ramine. The effects of the complex on cough elicited by ammomia in mice were studed. Results The results showed that the complex and dextromethorphan could inhibit cough reaction, while pseudoephedrine and chler pheniramine could not. The effects of compound pseudoephedrine were more potent than that of any component, but not than complex of its two components. Conclusion The data indicated that compound pseudoephedrine could relieve cough reaction and each of its components had a synergistic action.

Key words: Compound pesudoephedrine, Pseudoephedrine, Dextromethorphan, Chlerpheniramine, Relieving cough