Abstract: Aim The immunoregulative effects of different combination of herbs in a Chinese medicinal recipe Buzhongyiqitang were to be observed. Methods Decoctions of the whole recipe, of the simple Am, of the simple Gu, of the recipe with Am withdrawn and of the recipe with Gu withdrawn were separately given to spleen-asthenia mice in different groups. Three selected kinds of immune indexes were analysed. Results The whole recipe of Buzhongyiqitang could restore the red cell immunological function, NK activity and the value of TNF in spleen-asthe-nia mice to normal. The simple Am and the recipe with the Gu withdrawn could bring about the same result, except for a less efficacy. The simple Gu could not give the same effect and to certain extent, it would inhibit the immunological function of the red cells. Conclusion Since the efficacy of the whole recipe is better than that of the recipe with Gu withdrawn, the effect of Tu in the whole recipe remains to be important.

Key words: buxhongyiqitang, astrogulus , monhelicus , NK activity