Chinese Journal of Clinical Pharmacology and Therapeutics

A clinical trial of progestin-only contraceptive injectable Depo Geston in Chinese lactating and non-lactating women

Hao Zhuanye, Chen Sufang, Yang Dan, Zhou Huien, Luo Shiyuan, Lei Zhenwu, Shao Qingxiang, Sang Guowei

1997, 2(2): 81-84.

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A clinical trial of progestin-only contraceptive injectable Depo Geston in Chinese lactating and non-lactating women Hao Zhuanye Chen Sufang Yang Dan Zhou Huien Luo Shiyuan Lei Zhenwu Shao Qingxiang Sang Guowei (Damily Planning Research Institute, Zhejiang Academy of Medical Sciences, Hangzhou, 310013) Aim To evaluate the efficacy, side effects and acceptability of 3 monthly injectable contraceptive Depo Geston in lactating and non-lactating Chinese women. Methods All subjects were recruited in 3 clinics after giving datailed consultation and obtaining informed consent to receive im injection of Depo Geston at the 3 months interval for one year. Results No pregnancy occurred during one year study period. Overall discontin-uation rates for lactation and non-lactation women were 5. 05% and 11. 4%, respective-ly. The side effects mainly was irregular bleeding. The proportion of women complained of bleeding problems in non-lactation women(16. 1%) was higher than that in lactation women (5. 1%, P< 0. W). No other serious side-effects were observed. Conclusion Depo Geston is a highly effective, long-acting contraceptive, could have good acceptability after giving datailed advice. It is especially applicable to lactation women.

Change of soluble Interleukin-2 receptor and its significance in nephrotic syndrome patients

Zhang Daoyou, Ye Rengao, Li Youji, Li Huiqun, Lin Shanhong

1997, 2(2): 85-88.

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Aim To investigate the clinical significance of SIL-2R concentrations. Methods Serum and urine soluble interleukin-2 receptors (SIL-2R) were determined with the ELISA method in 36 cases of nephrotic syndrome patients and 20 cases of health volunteers. Results The serum and urine SIL-2R concentrations in the nephrotic stage group (252± 109u/ml, 167 ± 80u/ ml, n = 22) exceeded those in non-nephrotic stage group (120 ± 26u/ ml, 101 ± 46u/ml, n = 14, P<0. 01) and those in healthy controls (113 ± 110u/ml, 84 ± 19u/ml, n = 20, P< 0. 01). There were not any differences in serum and urine SIL-2R concentrations between non-nephrotic stage group and healthy controls (P> 0. 05). Serum SIL-2R con-centrations were correlated with serum creatinine (r = 0. 44, P<0. 01), and urine SIL-2R concentrations were correlated with urine protein excretion (r = 0. 48, P< 0. 01). Conclusion Higher concentration of SIL-2R can serve as an indicator of nephrotic syndrome and (or) renal function exacerbation.

A Clinical study on the effect of cisapride on improving gallbladder contraction function in patients with gallbladder stone

Fu Xianbo, Jia Jianwen, Miao Liying

1997, 2(2): 89-91.

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Aim It was to be ascertained whether gallbladder contraction function could be improved by taking cisapride orally. Methods The size, circumference, area and the largest contraction rate of gallbladder (CRG) after fat meal were compared between the control group (9 subjects) and the stone group (21 cases), and between those before and after taking cisapride orally, by ultrasonography. Results There was a lower CRG in the stone group (28. 6 ± 17. 3%) as compared with that in the controls (54. 7% ± 11. 3%, P = 0. 0030). The mean area of fasting gallbladder was significantly larger in the stone group (18. 3 ± 11. 8 cm²) than in the controls (12. 1 ± 2. 14cm², JP< 0, 05), but no significant differences in circumference and area of the gallbladder before and after cisapride administration were found. There was a significant increase of CRG (41. 1% ± 14. 7%) in the stone group after taking cisapride in comparison with that before taking cisapride (27. 5% ± 14. 7%, P = 0. 0134). The increased CRG was seen in 11 out of 13 patients with gallbladder stone (84. 6%) . Based on the C|^G before taking cisapride, there was a negative correlation between increased degrees of CRG in two groups, (r =-0. 5192). Conclusions Cisapride has the effect on improving galjbladder contraction function after fat meal in subjects with or without gallblader stone, wi|h an effect rate of 81. 8%

Effects of codonopsis pilosula, bletilla striata prepared rheum palmatum and their formuia on Experimental ulcer models in rats

Liu Haipeng, Chen Xiangtao, Wang Huili

1997, 2(2): 92-94.

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Aim and Methods Effects of codonoposis pilosula, bletilla, striata prepared rheum palmaturn and their formula respectively on experimental ulcer model induced by ethanol, ulcer model induced by pylorus-ligation and chronic ulcer model induced by ethanoic acid in rats were observed, and the amount of gastric secretion, gastric mucus and mucosa blood flow was also determined to provide clues to evaluation of their effects. Result The results showed that the drugs and their formula respectively decreased the idexes of ulcer in different models to varying degree, and that they increased the amount of gastric mucus and gastric muscosa blood flow. Conclusion Drugs have better cruative effect for gastric ulcer, and the effect may partly result from their influences on the mucus secretion and gastric mucosa blood flow.

The Effect of cyclosporin A and verapamil on psoriasis in experimental animal models

Yang Yan, Wang Hui, Wang Zongrui

1997, 2(2): 95-97.

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Aim The action of cyclosporin A (CSA) and verapamil (Ver) on psoriasis was studied. Method Mouse rail scale epithelium model and mouse vaginal epithelium model were set up. The effect of CSA and Ver on the number of mouse tail scale granule cell layer and the mitosis index of mouse vaginal epithelium were observed. Result CSA not only could increase the number of granul cell layer (P<0. 05), but also reduce the mitosis index and inhibit cell proliferation (P<0. 01). Ver only reduce the mitosis index and inhibit cell proliferation (P<0. 05). Conclusion CSA has effect on two psoriasis medels by controlling epithelium over-proliferation and making epithelium incomplete recutization ture to normal recutization, so it could interfere psoriasis well, but recutization while Ver only has effect on vaginal epithelium, showing that though Ver has therapeutic action, it also has toxin-side effect.

Protective effect of BQ-123, an endotheiin receptor antagonist, on the brain damage caused by cerebral reperfusion in rats

Liu Hong, Shu Siyun, Bao Xinming

1997, 2(2): 98-100.

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Aim The protectie effect of BQ-123 on the brain damage caused by cerebral ischemia reperfusion was to be observed. Methods The cerebral ischemia model was made by four-vessel occlusion method in SD rats. The reperfusion was performed for 72 hours, and then BQ-123 was injected intracerebrovertricularly in a volume of 0. 001ml at a dosage of 50μg/rat within 30 minutes after reperfusion. Results In the BQ-123 treated group, the number of survival neuron in the hippocampal CA1 was significantly greater than that in the untreated group (P<0. 01) and much smaller than that in the controls (P<0. 01). The behaviour test indicated that the reperfusion made the ability of study and memory in cerebral ischemia rats markedly reduced, and the BQ-123 treatment made the ability significantly improved (P <0. 01). Conclusion BQ-123 is useful in preventing the neuronal damage following the cerebral ischemia reperfusion in rats.

Protective effects of tetrandine on acute ischemic renal failure in rats

Sun Chengchun, Hao Junwen, Zhang Xia, Wang Jingxiang

1997, 2(2): 101-103.

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Aim To study the protective effects of tetrandine (Tet) on acute ischemic renal failure in rats. Methods Tet 20mg/kg, 40mg/kg once daily, for three days and one hour before operation was administered orally to rars. The models of renal ischemia and reperfusion in rats were built. The malondialdehyde (MDA), superoxide dismutase (SOD), Na⁺, K⁺-ATP ase and Ca²⁺-ATPase of renal tissue were determined and the histopathological structure of kidneys was obseved. Results In the reperfusion group, the level of MDA was increased and the levels of SOD, Na⁺, K⁺-ATP ase and Ca²⁺-ATP ase were decreased significantly. In the Tet group the level of MDA was decreased and the levels of SOD, Na⁺, K⁺-ATP ase and Ca²⁺-ATP ase were increased significantly. The wide denatufcition of epithelial cell of uriniferous xubules was observed by light microscope in the reperfusion group but little in the Tet group. Conclusion Tet has protective effects on acute ischemic renal failure in rats.

Effect of insulin on several vasocontrictive agents

Wang Feng, Liu Min, Wang Jingyuan, Lu Min, Cheng Yanjiang, Ji Xiaoshen, Lu Caiyi, Hao Yong

1997, 2(2): 104-106.

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Aim The effect of insulin on the vasocontrictive agents including noradrenaline, endothe-lin-1, KCI, angiotensin II and 5-hydroeytryptamine, was analysed. Methods Aortic rings of SD rats were used to investigate the influence of insulin for several vasocontrictive agents. Results Insulin was hypersensitive for noradrenaline, endothelin-1 and KCL, and incresed the effects of angiotensin II but no difference, buc had no effect on 5 ~ hy-droxytrypramine. Conclusion It suggests insulin could play an Important role in occurrence of hypertension.

Effects of theophylline on ECG and QEEG mapping in man and correlation between the effects and the drug level in saliva

Wu Shiyao, He Ping

1997, 2(2): 107-108.

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Aim This study was designed to evaluate the effect of theophylline on ECG and QEEG map-pong in healthy volunteers and correlation between the effects and the drug level in saliva. Methods The effects of theophylline on ECG and QEEG mapping in healthy volunteers were studied in a double-blind and placebo controlling. Results Two hours after taking theophylline 0. 4g, the amplitude of R wave in ECG rose from 9. 9 ± 2. 8mV to 12. 0 ± 3. 6mV(P < 0. 05); a₂ wave power in f_p lead and β₁ wave power in f₃ and f₄ leads increased from 1. 05 ± 0. 83 to 2. 08 ± 2. 22(P< 0. 05) and from 1. 75± 1. 35 to 3. 11±3. 51(P<0. 05) respectively; and the theophylline level in saliva was 7. 6 ± 0. 9 pg/ml, existing the correlation between the changes of R wave amplitude and ai wave power and the drug level in saliva (r = 0. 7933 and 0. 8264). Conclusion The experimental results indicated that the theophylline at treatment concentration could cause the changes of ECG and QEEG mapping in healthy volunteers, which was correlation with the level of the freedrug.

Piracetam and piracetam compound in treating benign hypomnesis of middle-sentle patients

Li Shulan, Du Zunming, Xu Cisun

1997, 2(2): 109-110.

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Aim and Methods To study the clinical effect of piracetam compound (PC) and piracetam on benign hypomnesis in middle, -senile patients, double-blind method was adopted to devide 60 patients (M42, F18, age 58. 0±7. 6a) into two equal groups. Patients in group A received PC 2 capsules, po, lid for-60 days, while the patients in group B received pirac-etam. Results The memory quotient (MQ) and MMSE were increased by 24. 3 ± 10. 9 and 2. 1 ± 1. 7 in group A and 11. 9 ± 6. 3 and 1. 5±1. 0 in group B, The MQ Was increased more significantly in group A than in group B (P< 0. 01). Conclusion Piracetam compound has better effect than piracetam alone in treating middle-senik benign hypomnesis.

Pharmacokinetic effect of cephradine on netilmicin sulfate

Yuan Cheng, Wang Jingxiang, Xue Zuoying

1997, 2(2): 111-113.

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Aim & Methods To study the effect of cephradine on pharmacokinetic action of netilmicin sulfate, the concentrations of netilmicin sulfate in serum and urine were determined by a high performance liquid chromatography-indirect photometric determination (HPLC-IPD) method at the wavelength of 262nm after intravenous drip of 5mg/kg of netilmicin sulfate in 14 patients who had been divided into two groups, with the patients in one group simultaneously taking orally cephradine. The data obtained were fitted with a PKBP-N1 program on computer. Results The disposition was conformed to a two-compartment model with T_1/2β = 2. 40±1. 01h and 4. 33±1. 43h(P<0. 01), and AUC_0~24h= 63. 42±30. 00mg/h·L and 78. 54±32. 88 mg/h · L(P<0. 01) in two groups. There was a remarkable discrepancy for the recla-mation of netilmicin in urine between two groups. Conclusion The bioavailability of netilmicin was raised and reclamation in urine descended with cephradine.

Effects of different combination of berbs in Buzhongyiqitang on immunoregulatin in spleen-asthenia mice

Wu Minyu, Mi Na, Sun Weimin

1997, 2(2): 114-116.

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Aim The immunoregulative effects of different combination of herbs in a Chinese medicinal recipe Buzhongyiqitang were to be observed. Methods Decoctions of the whole recipe, of the simple Am, of the simple Gu, of the recipe with Am withdrawn and of the recipe with Gu withdrawn were separately given to spleen-asthenia mice in different groups. Three selected kinds of immune indexes were analysed. Results The whole recipe of Buzhongyiqitang could restore the red cell immunological function, NK activity and the value of TNF in spleen-asthe-nia mice to normal. The simple Am and the recipe with the Gu withdrawn could bring about the same result, except for a less efficacy. The simple Gu could not give the same effect and to certain extent, it would inhibit the immunological function of the red cells. Conclusion Since the efficacy of the whole recipe is better than that of the recipe with Gu withdrawn, the effect of Tu in the whole recipe remains to be important.

Effects of potassium citrate granuals on blood electrolyte levels of patients with hypokalemia

Li Chuanyi, Zhou Ruihai, Zhang Dekui, Li Aiguo, Xhao Jianhua, Liu Hongtao, Bu Peili

1997, 2(2): 117-119.

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