Change of soluble Interleukin-2 receptor and its significance in nephrotic syndrome patients

Abstract

Abstract: Aim To investigate the clinical significance of SIL-2R concentrations. Methods Serum and urine soluble interleukin-2 receptors (SIL-2R) were determined with the ELISA method in 36 cases of nephrotic syndrome patients and 20 cases of health volunteers. Results The serum and urine SIL-2R concentrations in the nephrotic stage group (252± 109u/ml, 167 ± 80u/ ml, n = 22) exceeded those in non-nephrotic stage group (120 ± 26u/ ml, 101 ± 46u/ml, n = 14, P<0. 01) and those in healthy controls (113 ± 110u/ml, 84 ± 19u/ml, n = 20, P< 0. 01). There were not any differences in serum and urine SIL-2R concentrations between non-nephrotic stage group and healthy controls (P> 0. 05). Serum SIL-2R con-centrations were correlated with serum creatinine (r = 0. 44, P<0. 01), and urine SIL-2R concentrations were correlated with urine protein excretion (r = 0. 48, P< 0. 01). Conclusion Higher concentration of SIL-2R can serve as an indicator of nephrotic syndrome and (or) renal function exacerbation.

Key words: soluble interleukin-2 receptor, nephrotic syndrome, serum creatinine, pro-teinuria

CLC Number:

R692

Zhang Daoyou, Ye Rengao, Li Youji, Li Huiqun, Lin Shanhong. Change of soluble Interleukin-2 receptor and its significance in nephrotic syndrome patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1997, 2(2): 85-88.

References

1 Glassock RJ, Adler SA, Ward HJ, et al. Primary glomerular diseases. In: Brenner BM, Rector FC. The Kidney. 4th eds. Philadelphia. W. B. Saunders Company, 1991-1182
2 Nassberger L, Sturfelt G, Thysell H. Serum levels of ssolable interleukin-2 receptor are dependent on the kidney function. Am J Nephrol, 1992, 12:401
3 Mandreoli M, Bcltrandi E, Casadei Maldini M, et al. Lymphocyte release of soluble IL-2 receptors in parents with minimal change nephropathy. Clin Nephrol, 1992, 37:177
4 Ohno I, Gomi H, Matsuda H, et al. Soluble IL-2 receptor in patients with primary nephrotic syndrome. Japanese) Nephrol, 1991, 33:483
5 Yorioka N, Hirabayashi A, Kanahara K, et al. Serum soluble interleukin-2 receptor in patients with glomerulonephritis. Am J Nephrol, 1990, 10, 181
6 Maruyama K, Tomizawa S, Shimabucuro N, et al. Effect of supernatants derived from T-lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries., Nephron, 1989, 51:73
7 Novick D. Engelmann H, Wallach D, et al. Soluble cytokine receptors are present in normal human urine. J Exp Med, 1989, 170:1409
8 Chilosi Mf Semenzato G, Vinante F, et al. Increased levels of soluble interleukin-2 receptor in non-Hodg kin' vS lymphomas： Relationship with clinical, histological and phenotypic features. Am J Clin Pathol, 1989, 92:186
9 Manoussakis MN, Papadopoulos GK, Drosos AA, et al. A soluble interleukin-2 receptor molecules in the serum of patients with autoimmune disease. Clin Immunol Immunopathol, 1989, 50:321
10 Kloster BE, John PA, Miller LE, et al. Soluble interleukin-2 recepters are elevated in patients with AIDS or at risk of developing AIDS. Clin Immunol Im-raunopathol, 1987, 45: 440
11 Tsai CYf Wu. TH, Sun KH, et al. Increased excretion of soluble interleukin-2 receptors and free light chain immunoglobulins in the urine of patients with active lupus nephritis. Ann Rheumat Dis, 1992, 51: 168
12 Laut J, Senitzer D, Petrucci R, et al. Soluble interleukin-2 receptor levels in lupus nephritis. Clin Nephrol, 1992, 38:179

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