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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 1997, Vol. 2 ›› Issue (3): 165-168.

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Concentration-dependent effect of cyclosporine on plasma lipid in renal transplant recipients

Xu Feng, Wu Zhaohui, Zhang Zhongyi, Zou Hengqing   

  1. Department of Clinical Pharmacology, Zhujiang Hospital, First Military Medical University, GuangZhou 510282
  • Received:1997-06-25 Revised:1997-07-25 Online:1997-09-26 Published:2020-12-04

Abstract: Aim To investigate the concent ration-dependent effect of cyclosporine on plasma lipid.Methods Pre-and post-transplant plasma lipid and cyclosporine whole blood concent ration were determined in 16 renal transplanted recipients with stable graft function.Results No statistically significant correlations were found between cyclosporine whole blood concent ration and plasma cholesterol and triglyceride increase-difference.However, post-t ranplant plasma cholesterol level was increased in renal transplanted recipients with high blood concent ration of cyclosporine(P<0.05).Conclusion The effect of cyclo sporine on plasma lipid in renal transplanted recipient is concent ration-dependent.

Key words: cyclo sporine, adverse drug reaction, plasma lipid, renal transplantation

CLC Number: