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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 1997, Vol. 2 ›› Issue (4): 253-255.

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Effects of propofol and ketamine on Na+, K+-ATPase activity of synaptosomes in rat brain in vivo

Hu Xingguo, Wang Jun, Zeng Yinming, Duan Shiming, Dai Tijun, Xu Pengcheng, Wan Lingli   

  1. Research Institute of Anesthesiology, Xuzhou Medical College, Xuzhou 221002
  • Received:1997-07-30 Online:1997-12-26 Published:2020-11-30

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Abstract: Aim To investigate the effects of propofol and ketamine on Na+, K+-ATPase activity in rat brain synaptosomes.Methods Thirty SD rats were divided randomly into three groups. The aminals were given intraperitoneally (ip)normal saline 10ml/kg (control group), propofol 100mg/kg or ketamine 100mg/kg, respectively. Na+, K+-ATPase activity of synaptosmes was assassed by spectrophotometric analysis.Results In the propofol group Na+, K+-ATPase activities of cerebrocortical, hippocampal and brain stem synaptosomes were significantly inhibited as compared with those in the control group (P<0.01). In the ke-tamine group, Na+, K+-ATPase activities of cerebrocortical and brain stem synaptosomes were significantly lower than those in the control group (P<0.01). Conclusions The general anesthesia effects of propofol and ketamine may be related to the inhibition of Na+, K+-ATPase activity of brain synaptosomes in rats.

Key words: propofol ;ketamine ;Na+, K+-ATPase ;cerebral synaptosomes

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