Abstract: Aim The curative effect of TAA-1, a new component of Amethy stoidin, on rabbit endo cardit is induced by α-hemolytic streptococus was observed.Methods A sterile polythelene catheter was inserted through the right carotid artery of rabbits into the ventricle and 24 h after the operation, every rabbit was given 109CFU α-hemolytic streptococcus from earvein.After 24 h, the animals were divided into two groups.Animals in the control group were treated with NS, 0.2 ml · kg^-1 and in the treatment group with TAA-1, 0.25 mmol · kg^-1, ipqd for 7d.All the animals weRescarified, somet issues of the heart were used for examination of the histological changes and some for observation of the aortic and ventricale neoplasm.Results In the treatment group, the neoplasms weResmaller. Both the count of organisms in blood and neoplasm and the injury degree of myocardium were much less than in the control group.Conclusion TAA-1 has curative effect to endocarditis induced by α-h emolytic streptococcus.

Key words: TAA-1, amethy stoidin, α-hemolytic streptococcus, rabbit