Abstract: Aim To explore the treating effect of vitamin C(VitC)on lipid peroxidation injury of liver after ischemiz-reperfusion.Methods A model of hepatic ischemia-reperfusion in rabbits was established to invest igate the alterat ions of lipid peroxide by measuring malo ndialdehyde (MDA)and vitamin E (VitE)in plasma or liver t issue, and to observe the morpholog icachanges of hepatocytes. A large dose of VitC was given to the model aninals to observe its preventing and treating effects on lipid peroxidation injury of the liver (VitC in a dose of 0.25 g ·kg^-1).Results The degree of lipid peroxidation was streng thened and the morphological changes of hepatocy tes were more obvious during hepatic ischemia-reperfusion when VitC was given before ischemia and before reperfusion, respectively, the degree of lipid peroxidation was remarkabley weakened and the abnormal changes of hepatocytes weResig nificantly at tenuated.Conclusion VitC in a dose of 0.25 g · kg^-1 would inhibit or ameliorate lipid peroxidation injury of liver after ischemia-reperfusion.

Key words: hepatic ischemia-reperfusion, lipid peroxidation injury, vitamin C