Abstract: Aim The bioavailability and bioequivalence of clarithromycin disperse tablets (as test preparation)and Limaixian tablets (as reference preparation)weRestudied in 8 healthy volunteers with a double-cross design test.Methods The serum concentrations of clarithromycin after a sig le oral dose of 500 mg of the test preparation or reference preparation were determined by microassay method. Datum were analysed with 3p97 pharmacokinetic programme and two-one sidedt test and (1-2α)confidence interval analysis.Results The Ka, t_1/2 (α), t_1/2(β), C_max, AUC (0 ~ ∞)of the two preparations were 0.7843 and 0.5893 h^-1, 1.7324 and 2.3140 h, 4.1449 and 3.8635 h, 2.2308 and 1.8742μg ·ml^-1, 17.7410 and 16.2751 μg · h ·ml^-1, respectively.The relative bioavailability of clarith romycin desperse tablet was 106.21 %.Conclusion The bioequivalence of AUC between test and reference preparations, phases and subjects shows no significant differences (P>0.05).

Key words: clarithromycin disperse tablets/limaixian tablets, relative bioavailability, pharmacokinetics