Abstract: Aim To evaluate and compare the feasibility and clinical outcomes of cutting balloon angioplasty (CBA) and cutting balloon combined with intravascular brachy therapy (IBT) for the treatment of coronary in-stent restenosis.Methods 41 patients (47 lesions) with in-stent restenosis(ISR) were randomly divided into three groups, the patients in the control group were t reated by plain old balloon angioplasty (POBA), and in CBA group with CBA, and in CBA +IBT group by CBA combined with IBT.All the patients were followed up for 6 to 8 months.The end-points of the observ ation were angina pectoris (AP) accompanied by elect rocardiog ram changes similar to before the t reatment, myocardial infarction (MI), target-lesion revascularization (TLR) and nontarget-lesion revascularization (N TLR).If no thing happened, acute gain (AG), late loss (LL), loss index (LI), and re-restenosis (RRS) w ould be compared among the three groups by quantitat ive coronary angiography after 6 to 8 months.Results The incidences of AP, MI, TLR and NTLR were similar in three groups(P>0.05);the levels of LL, LI, RRS in CBA group and CBA +IBT group were significantly lower than those in control group (P<0.05) and AG in CBA group was higher than that in other two groups(P<0.05).Conclusion CBA and IBT are effective in treatment of ISR, and CBA seems to be prior to CBA +IBT.

Key words: cut ting balloon, stent, intravascular brachy therapy, restenosis, re-restenosis