Abstract: AIM: To study protective effest of Zn-pipemidate on experimental gastric ulcer and its mecha-nism. METHODS: Pylous-ligated, stess-induced, acetic acid-induced and reserpine-induced gastric ulcers in rats or mice were used in experiment.Rats or mice were randomly divided into five groups including car-boxymethylcellulose (CMC), cimetidine and three doses of Zn-pipemidate (0.025, 0.05, 0.1 g·kg^-1 ).The drugs were given ig, once a day, for 5d.Gastric juice, out-put of pan-acid, pepsin activity and the volume of mucusgas-tric wall were determined in pylorus-ligated gastric ulcer in rats.RESULTS: Zn-pipemidate could inhibited the formation of all gastric ulcer models in a dose-dependent manner.All of the three doses of Zn-pipemidate groups could reduce out-put of pan-acid (P<0.01) and pepsin activity, and increase the volume of mucus gastric wall (P<0.01).CONCLUSION: Zn-pipemidate can pro-tect experimental gastric ulcer.Its mechanism is related to increasing protective factors and reducing damaging factors of gastric mucosa.

Key words: Zn-pipemidate, gastric ulcer, gastric acid, pepsin activity, barrier mucus