Protective effects of imipramine on ischemic injury in cultured rat cerebral neurons

Abstract

Abstract: AIM: To study the protective effects of Imipramine ( Imi) on ischemic injury in cultured rat cere-bral cortical neurons.METHODS: Cortical neurons of fetal rat were cultured in vitro.The protective effects of Imi on ischemic injury in cultured rat cerebral neurons were observed.RESULTS: Imi ( 10^-5, 10^-6, and 10^-7 mol·L^-1 ) reduced the number of cell death, low-ered LDH,NO, and MDA content, and increased of activ-ity of SOD.CONCLUSION: Imi can protect rat cerebral cortical neurons from ischemic injury and toxicity of Glu. And it maybe attribute its to antioxidation and calcium an-tagonism .

Key words: imipramine, glutamate, cortical neuron, cell culture, sodium dithionite, cerebral ischmia

CLC Number:

R965.2

XU Yong, JI Bian-Sheng, GAO Yuan, LIU Hong, XU Qing-Rong, ZHANG Gui-Qing. Protective effects of imipramine on ischemic injury in cultured rat cerebral neurons[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(2): 134-137.

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