Abstract: AIM: To evaluate the efficiency of buflomedil hydrochloride injection ( Buf ) in the treatment of the damage of peripheral nerve induced by diabetes (DPN). METHODS: 28 patients with DPN were given Buf ( 150 mg·d^-1, iv gtt) and another 28 patients were used routine therapy. The treatments lasted for 15 d. RESULTS: The total efficiency rate was 96. 5 % in Buf group, while it was 57. 1 % in routine therapy group ( P <0. 01). The conduction speed of nerve in buf group was greatly improved in comparison with the routine therapy ( P <0. 01). CONCLUSION: It is reliable for Buf to treat the damage of peripheral nerve induced by diabetes.

Key words: Buflomedil hydrochloride injection, diabetes, peripheral nerve