Table of Content

Volume 7 Issue 4
26 August 2002

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Comparison of vasoconstrictive effect of histamine on the isolated rabbit central and peripheral arteries in vitro and its mechanism

WANG Hui-Jing, WU Ai-Zhen, YAO Ming-Hui

2002, 7(4):  289-292. 

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AIM: To compare the effects of histamine and its antagonists on tension of isolated rabbit basilar and mesenteric artery in vitro, and to observe the role of Ca²⁺ in histamine-induced response. METHODS: The doseresponse curves induced by histamine were recorded on the isolated rabbit central and peripheral arteries in different doses of diphenhydramine, cimitidine, and nifidipine. RESULTS: Histamine could cause contraction of basilar and mesenteric isolated arteries. Diphenhydramine and nifidipine antagonized these effects, while cimitidine enhanced this effect. CONCLUSION: There may be different receptors densities in different rabbit arteries; histamine shows the vasoconstrictive effect on both brain and mesenteric arteries; and the vasoconstrictive effect mainly produces via Ca²⁺ inflax.

Effect of monascus purpureus fermented rice on fatty liver in quails

WANG Yin-Ye, WEI Wei, LI Chang-Ling

2002, 7(4):  293-295. 

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AIM: To investigate the effect of monascus purpureus fermented rice ( MR) on alcohol-fatty liver model in quails. METHODS: A fatty liver model was established in quails, then the lipid levels of the models were tested in both plasma and liver, and the examination in the pathological-histology of liver was conducted. RESULTS: 1. 6 g·kg^-1·d^-1 of MR given orally for 20 d significantly decreased TC, TG and LDL ( P < 0. 01) in serum, and TC, TG in liver of quails. 0. 8 g· kg^-1·d^-1 of MPFR also decreased TC and LDL in serum ( P <0. 05) and TC in liver ( P <0. 01). MR lowered the rate of liver fatty degeneration with a dose-dependent manner and reduced the degree of liver fatty degeneration. CONCLUTION: MR shows a therapeutic efficacy on alcoholic fatty liver model in quails, suggesting that it may be used as a kind drug or a kind of health food in prevention or treatment of patients with fatty liver.

Effect and mechanism of JianNao mixture on function of learning and memory in mice

SHI Hong, REN Juan, QIAN Bo-Chu, ZHANG Wang-Gang, CHEN Guo-Sheng

2002, 7(4):  296-298. 

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AIM: To observe the effect and mechanism of Chinese traditional medicine JianNao mixture on function of learning and memory in memory disorder mice. METHODS: Step down test, step through test and “Y” maze test were used to examine the function of learning and memory in memory disorder mice induced by scopolamine, sodium nitrite and alcohol, and in dementia model mice induced by D-galactose and aluminum chloride. Cholinesterase activity in brain, LPO and SOD in blood were measured. RESULTS: JianNao mixture could promote both the learning and memory function in impaired acquisition, consolidation and retrieval of memory in memory disorder mice induced by scopolamine, sodium nitrite and alcohol, respectively. It also could reduce wrong times and prolong latency in mice' s step through test, depress cholinesterase activity of brain in aluminum chloride model mice, reduce wrong times in mice' s “Y” maze test, enhance SOD activity of whole blood and decrease LPO content of brain in D-galactose model mice. CONCLUSION: JianNao mixture can improve the function of learning and memory in memory disorder mice. The mechanism may be due to improve the cholinergic function and the balance of free radical in vivo.

Enhancement of ginsen-stem-leaves to the antitumor effect of 5-FU in mice inoculated S180

CHEN Fang, WU Tie, FU Yu-Ping, LIU Xiao-Qing

2002, 7(4):  299-301. 

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AIM: To observe the enhancement of ginsen-stem-leaves (GSL) to the antitumor effect of 5-FU in mice inoculated S180. METHODS: The different combinations of GSL and 5-FU were used to examine the inhibition rates of tumor growth in KM mice inoculated S180. RESULTS: The combination of GSL ( 15 mg·kg^-1) and 5-FU ( 1. 5 mg·kg^-1) obtained 26. 90 % of inhibition rates of tumor growth ( P <0. 05), and did not inhibit the thymus. The antitumor rate of 5-FU ( 25 mg·kg^-1) was 36. 61 %, and the dose markedly decreased the weight of thymus. CONCLUSION: The combination of GSL ( 15 mg·kg^-1) and 5-FU ( 1. 5mg·kg^-1) can markedly inhibit the tumor growth of S180 inmice, but does not decrease the weight of thymus, suggesting that the combination may decrease the side effect produced by 5-FU.

Effects of chromium rutin on metabolism of blood lipid in rats

LIU Yi-Chun, LIU Gang

2002, 7(4):  302-305. 

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AIM: To study the effects of chromium rutin synthesized with rutin and chromium (Ⅲ) on metabolism of blood lipid. METHODS: The effects of chromium rutin on metabolism of blood lipid were evaluated by the changes of triglyceride, cholesterol, HDLcholesterol, and LDL-cholesterol in normal rats and the rats with high blood lipid. RESULTS: Chromium rutin could increase the blood chromium, decrease the concentrations of triglyceride, cholesterlo and LDL-cholestelol, and increase the concentration of HDL-cholesterol in normal and the rats with high blood lipid rats. CONCLUSION: Chromium rutin has an effect on the blood lipid in rats.

Effects of simvastatin on myocardial fibrosis in NO-deficient hypertensive rats

YI Chun-Tao, CHENG Xiao-Shu, YU Jian-Hua, YAN Ding-Hong, SU Hai, WU Qing-Hua

2002, 7(4):  306-310. 

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AIM: To investigate the effects of simvastatin on myocardial fibrosis in NO-deficient hypertensive rats. METHODS: Twenty-four male Wistar-Kyoto rats were divided into three groups: Control ( C) group, L-NAME ( L) group, and L-NAME plus Simvastatin ( L +S) group. The levels of ACE and Ang Ⅱ in plasma and myocardial tissue, and the contents of hydroxyproline concentration in myocardial tissue were measured after 8 weeks. The values of CVF, PVCA and the hydroproline concentration ( HC ) were studied using the methods of pathological examination combined with computed processing. RESULTS: The activity of ACE in serum in L group was lower than that in C group ( P <0. 01). Simvastatin treatment did not significantly increase the activity of ACE compared with L group ( P >0. 05). However, the activity of ACE in myocardial tissue was lower than that of C group ( P <0. 05). Although the levels of Ang Ⅱ in plasma were not altered by L-NAME ( P >0. 05), the concentrations of Ang Ⅱ in myocardial tissue ( P < 0. 01) were significantly increased in L group compared to C group. Simvastatin significantly decreased the levels of Ang Ⅱ in myocardial tissue ( P <0. 05). The hydroxyproline concentration and the value of PVCA and CVF in L group were significantly higher than that in C group ( P <0. 01), which were significantly attenuated by simvastatin tratment ( P <0. 05). CONCLUSION: Simvastatin may decrease the production of Ang Ⅱ and attenuate myocardial fibrosis via reducing the activity of ACE in NOdeficient hypertensive rats.

Study on experimental model of transplacental infection of coxsackievirus B₃ from the mother to the fetus in late gestation mice¹

SHENG Xiao-Rong, WU Yi-Lun, JIA Xue-Mei, HUANG Zhen-Wu, WU Na-Xin, WANG Hui-Zhu, QI Wei-Qin, XIA Yi-Ming, SU CHENG-Qin

2002, 7(4):  311-313. 

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AIM: To study the possibility and conditions of transplacental infection of coxsackievirus B3(CVB₃) from pregnant mice to their fetuses and newborns. METHODS: Coxsackievirus B₃ strain causing balb/c mice myocardial injury ( CVB_3m ) was inoculated with 10⁵ TCID₅₀ in dose into the mother mice at 6-7 days (early gestation), 9-10 days ( middle gestation) and 17-18 days ( late gestation) of gestation, in contrast with non-pregnant mice. Some placentas and fetuses were removed by caesarean section before mothers partusing; some mothers and their babies were sacrificed after parturition, and virus isolation, serological and pathological tests were performed. RESULTS: Viramiae was observed in mother mice of late-gestation inoculated with CVB_3m at a fit amount on the second day after inoculation, while no newtralizing antibody to CVB_3m was detected in blood. The virus was isolated from cardiac muscles of inoculated mother mice in different gestation and the controls. The virus was also isolated from some placentas and fetuses, and both sera and cardiac muscles of infants in the late gestation ( virus titer were all 10 ^-2—10^-3). On d 7 of inoculating virus, pregnant and non-pregnant mice titers of neutralizing antibody to CVB_3m in sera were all between 1 ∶160 and 1 ∶320. Under the electromicroscopy, some cardiac muscle cells of mother or infant mice appeared with morphological changes and little hollow bubbles occured in cytoplasm. The fibers broke off, and the bright and dark belts became indistinct. CONCLUSION: The amimal model, intraplacental passage of CVB₃from pregnant mother in late gestation to fetus in mice, is a benefitial tool to study enterovirus diseases in human perinatal period.

Effect of l-menthol on mucosa absorption of ciprofloxacin

ZHAO Huai-Jun, WANG Hui, FENG Jian-Qing, HUANG Jin-Shui

2002, 7(4):  314-316. 

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AIM: To investigate the effect of l-menthol on the absorption of ciprofloxacin (Cip)via the mucosa. METHODS: Mucosa absorption experiment and deposit effect were made on a two-cells diffusion apparatus in vitro to calculate permeation coefficients. RESULTS: With increasing of the concentration of Cip, the permeation coefficient of mucosa absorption showed a increasing tendency, but deposit effect declined significantly. After using l-menthol, the permeation coefficient of Cip showed a declining tendency. Especially at 0. 2 percent concentration of l-menthol, the decrease level was more obvious than other groups (P <0. 01), but its deposit effect was the largest. CONCLUSION: L-Menthol could decrease permeation coefficient of mucosa absorption of Cip and obviously enhance deposit effect of Cip.

Effect of air plant on lymphocyte proliferation, IL-2 production and bone marrow proliferation in mice

XU Qing-Rong, HU Xue-Mei, QIU Shi-Chui, HAN Zhao-Dong, LI Shu-Chui, XU Li-Hua

2002, 7(4):  317-319. 

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AIM: To study the immune function of air plant in mice. METHODS: 80 % and 50 % ( water extract of air plant were given to mice ( ig ), and the spleen lymphocyte proliferation, IL-2 production and bone marrow proliferation were observed. RESULTS: Compared with control group, the lymphocyte proliferation increased significantly in air plant group ( 8 g·kg^-1, ig ) ( P <0. 01), and IL-2 production increased obviously ( P <0. 05). There were not obvious effects on the proliferation of bone marrow. Low dose ( 5 g·kg^-1, ig ) of air plant did not show such effects. CONCLUSION: Air plant can enhance immune function in mice.

Muticentral study of oral swine serum immunoglobulins in treatment of infantile rotavirus enteritis

SHEN Zhen-Yu, QIU Xiao-Shan, CHEN Su-mei, LI Wen-Yi, XIE Yan-Ming, CHENG Shao-Jie, OU Wen-Ji, YUAN Shi-Zhen

2002, 7(4):  320-323. 

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AIM: To evaluate efficacy and safety of oral swine serum immunoglobulins in treatment of infantile rotavirus enteritis. METHODS: 322 infants with rotavirus enteritis were randomly divided into three groups: Double-blinded control trial was carried out in 243 inpatients randomly divided into two groups (128 infants received oral swine serum immunoglobulins in the treatment group, 115 infants received placebo in the control group), and 79 outpatients as the open group received oral swine serum immunoglobulins. Every group was received 0. 5 ml·kg^-1 of oral swine serum immunoglobulins or placebo thrice daily for 3 days. RESTULTS: The total therapeutic effective rate (cure and apparent effect)and curative rate were 73. 5 % and 38. 3 % respectively in the treatment group, significantly higher than 51. 3 % and 14. 8 % in the control group (P <0. 01).The therapeutic effect of the open group was similar to the treatment group. The total therapeutic effective rate and curative rate were 81 % and 39. 2 % respectively (P >0. 05). CONCLUSION: The oral administration of swine serum immunoglobulins is effective, safe and convenient in treating rotavirus enteritis of infants.

Effects of irbesartan on blood pressure and heart rate variability in patients with essential hypertension

YUAN Fang, DU Song, WANG Liu-Yi, WANG Li-Xia

2002, 7(4):  324-326. 

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AIM: To study the effects of irbesartan on blood pressure and heart rate variability ( HRV) in patients with essential hypertension ( EH). METHODS: 40 patients with EH received 150-300 mg·d^-1 irbesartan for 8 weeks. The changes in blood pressure were assessed. The time-and frequency-domain measurements of HRV from 24 hours ambulartory electrocardiographyic recordings were analyzed in 35 healthy controls and in patients with EH before and after the treatment. RESULTS: Compared to baseline, the systolic and diastolic blood pressure decreased from 21. 62 ±0. 47/12. 01 ± 0. 32 kPa to 18. 90 ±0. 32/8. 01 ±2. 35 kPa in the irbesartan groups, and respond rates were 73. 1 %.Compared with controls, the standard deviation of normal-to-normal intervals (SDNN), rate-mean-square of the differences of successive RR intervals ( RMSSD), the percentage of RR intervals differing >50 ms ( PNN50 ) and the high frequency ( HF) in patients with EH were decreased, While the ratio between low frequency and high frequency ( LF/ HF) were increased. After the treatment of irbesartan, the values of SDNN, RMSSD, PNN50, and HF were increased, and the LF/HF was decreased significantly. CONCLUSION: Irbersartan can increase the lowed HRV in patients with EH, which improves the cardiovascular automatic function.

Weight relief of sibutramine in treatment of obesity with different body weight

WANG Hui, CHEN Bing

2002, 7(4):  327-330. 

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AIM: To observe the effect of sibutramine in the treatment of obesity with different body weight. METHODS: Forty overweight subjects were divided into three groups according to their BMI: Group 1 ( n =10), the early stage of obesity; Group 2 ( n =11), obesity in degree Ⅰ; and Group 3 ( n =19), obesity in degree Ⅱ. The patients conformed to the same standards of diet, sports and life style, and then took sibutramine 10 mg a day for 12 weeks. RESULTS: After taking the medicine for two weeks, the efficacy rate was 45. 5 %( 5) in Group 2 and 94. 7 % ( 18) in Group 3 ( P <0. 01); four weeks later, 81. 8 % ( 9) in Group 2 and 5. 8 % ( 3) in Group 3; the obvious effect rate was 9. 1 % ( 1) in Group 2 and 84. 2 % ( 16) in Group 3 ( P <0. 01). After 12 weeks, the efficacy rate was 55. 6 % ( 5) in Group 1, 36. 4 % ( 4) in Group 2; the obvious effect rate was 63. 6 % ( 7) in Group 2 and 100 % ( 19) in Group 3 ( P <0. 01). CONCLUSION: Sibutramine is safe and efficient in the treatment of obesity with different body weight. The effect increases with body weight increasing.

Comparison of two methods of dialysis in the treatment of diabetic nephropathy with uremia

ZANG Cui-Ping, YE Ren-Gao, YANG Xiao

2002, 7(4):  331-333. 

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AIM: To compare the advantages and disadvantages between hemodialysis (HD) and continuous ambulatory peritoneal dialysis ( CAPD) in the treatment of diabetic nephropathy with uremia. METHODS: The survival rate, main complications, and the cause of death were compared between 61 cases of diabetic nephropathy with uremia received CAPD and 48 cases received HD. RESULTS: The patients with cardiovascular disease, and retinopathy, or age >70 years before dialysis, treated by CAPD, had less complications and higher life quality in comparison with HD. CONCLUSIONS: CAPD is suitable for the patients of diabetic nephropathy with uremia, system arteriosclerosis, cardiovascular instability, and retinopathy, or age >60 years.

Clinical evaluation of the efficiency of controlled-release formulation of glipizide in the treatment of type II diabetes mellitus

WANG Zhan-Jian, WANG Yan, SONG Qing-Fang, LIU Bo, ZHOU Ya-Ru

2002, 7(4):  334-336. 

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AIM: To compare the efficacy between a once-daily controlled-release formulation of glipizide ( CRFG) and immediate-release glipizide ( IRG) in patients with type Ⅱ diabetes mellitus. METHODS: 80 patients with type Ⅱ diabetes mellitus were divided into the CRFG group and the IRG group to observe the levels of blood glucose and insulin after the treatments. RESULTS: CRFG given qd and IRG given bid or tid showed a similar effect, but the levels of fasting and post prandial insulin in latter was higher than that in the former. CONCLUSION: The controlled-release formulation of glipizide can effectively control blood glucose without hyperinsulinemia in patients with type Ⅱ diabetes mellitus.

Hemoperfusion in treatment of overdose digoxin poisoning

YANG Hong-Jun, YUAN Xin-Ru, ZHANG Xi-Gang, NIU WEN-Kai

2002, 7(4):  337-338. 

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AIM: To observe the efficacy of hemoperfusion ( HP) to treat one case suffering from overdose digoxin poisoning. METHODS: HA 330 ml and YT-160 hemoperfusion cartridges were used and blood vessel was femoral vein, single needle and two-chamber catheter. Four HP were done. RESULTS: The blood digoxin level were 16 μg·L^-1 before and after the 1st HP, 9. 22 μg· L^-1 at the 2nd, 12. 4 μg·L^-1 before the 3th, 10. 45 μg· L^-1after the 3th, 3. 22 μg ·L ^-1before the 4th, and 2. 84 μg·L^-1 after the 4th HP. CONCLUSION: This case demonstrats that multiple HP at different period may decrease the blood digoxin level step by step.

Clinical evaluation of the efficiency of buflomedil hydrochloride injection in the treatment of the damage of peripheral nerve induced by diabetes

ZHANG Ling, JIE Xiao-Xia, WANG Su-Qin

2002, 7(4):  339-340. 

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AIM: To evaluate the efficiency of buflomedil hydrochloride injection ( Buf ) in the treatment of the damage of peripheral nerve induced by diabetes (DPN). METHODS: 28 patients with DPN were given Buf ( 150 mg·d^-1, iv gtt) and another 28 patients were used routine therapy. The treatments lasted for 15 d. RESULTS: The total efficiency rate was 96. 5 % in Buf group, while it was 57. 1 % in routine therapy group ( P <0. 01). The conduction speed of nerve in buf group was greatly improved in comparison with the routine therapy ( P <0. 01). CONCLUSION: It is reliable for Buf to treat the damage of peripheral nerve induced by diabetes.

Clinical evaluation of benazepril alone and combined with losartan in the treatment of congestive heart failure

TONG Xue-Min, HU Zhao-Liang, CHENG Sheng-Jun

2002, 7(4):  341-343. 

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AIM: To evaluate the efficacy of benazepril alone and combined with losartan in the treatment of congestive heart failure ( CHF). MATHODS: 34 patients with class Ⅱ-Ⅳ( NYHA) CHF were divided into two groups: benazepril group and benazepril +losartan group. The treatment course lasted 3 mon. RESULTS: NYHA class in both groups were significantly improved. There was no significant difference in effective rate between two groups ( 88. 9 % vs 87. 5 %, P >0. 05). However, benazepril +losartan group was better than benazepril group in improving heart composition and function ( P <0. 05). CONCLUSION: The combination of benazepril and losartan is prior to benazepril alone in the treatment of CHF.

Clinical observation of interferon α-1b combined with oxymatrine in the treatment of chronic hepatitis B

ZHANG Jing-Ling, GU Jing-Jing, WANG Tian-Dong

2002, 7(4):  344-346. 

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AIM: To observe the efficacy and side effects of interferon α-1b ( interferon) combined with oxymatrine in the treatment of chronic hepatitis B. METHODS: 87 patients were randomly divided into two groups: 45 patients in treatment group were given interferon 30 μg ·d^-1( im) for 4 wk, then 30 μg ·d^-1 ( im, qod) combined with oxymatrine 600 mg·d^-1( im) for 3 mon; 42 patients in control group were given the same dose of interferon as above only. After completion of therapy, liver function and markers of HBVM were compared between the two groups. RESULTS: The rates of ALT decreased to normal range in treatment group and control group were 88. 9 % and 60 %, respectively ( P <0. 05). The rate of HBeAg turned to negative was 55. 6 % in treatment group and 35. 7 % in control group; the rate of HBV-DNA turned to negative was 57. 8 % in treatment group and 42. 9 % in control group ( P <0. 05). Side effects were not found in the two groups. CONCLUSION: Interferon α-1b combined with oxymatrine can improve liver function and inhibit HBV replication. It suggests that the combination may be a scheme in the treatment of chronic hepatitis B.

Clinical evaluation of radiotherapy combined IL-2 in the treatment of the transferred remnant of nasopharyngeal carcinoma in jugular lymph

LIANG Ping, SU Zhen-Dong, LIANG Jing-Ying

2002, 7(4):  347-348. 

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AIM: To evaluate the effects of radiotherapy combined IL-2 in the treatment of the transferred remnant of nasopharyngeal carcinoma in jugular lymph. METHODS: Treatment group ( n =32) was given radiation DA 6000-6800 cGy combined an injection of IL-2 4 ( 104 u ( three times each week). A routine radiation DA 6000-6800 cGy was adopted as a control group in another 31 cases. RESULTS: Lymph disappearance rate at treatment and control group reached 93. 8 % and 71. 0 %, respectively ( P < 0. 05); jugular humorless rate was 66. 7 % and 33. 3 %, respectively ( P <0. 05). The survival rates of 1, 2 and 3 year ( s) reached 73. 8 %, 59. 5 % and 42. 9 % in the treatment group, and 51. 2 %, 36. 6 % and 22. 0 % in the control group, respectively ( P <0. 05). The adverse actions did not show obvious difference between two groups. CONCLUSION: Incremental radiation combined partial injection of IL-2 is an effective remedy in the treatment of the transferred remnant of nasopharyngeal carcinoma in jugular lymph.

Clinical analysis of the dead hypoglycemic coma related to xiaoke pills in old patients with diabetes

LI Yun-Quan, YIE Mei-Yin, LIMin-Hua

2002, 7(4):  349-350. 

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AIM: To analyze the relation of hypoglycemic coma and xiaoke pills. METHODS: The relation of hypoglycemic coma and xiaoke pills were analyzed retrospectively from the five cases of old patients. RESULTS: All the five old patients with diabetes died of hypoglycemic coma on the seventh day to the thirteenth day, after taking xiaoke pills. CONCLUSION: It must be cautious for xiaoke pills to treat diabetes in elderly patients.

Clinical observation of the effect of lansoprazole preventin irritable ulcerous hemorrbage in acute cerebral apoplexy

ZHANG Feng-Lan, ZHAO Jun-He, LI Yan

2002, 7(4):  351-352. 

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Clinical efficacy of large dosage of liyuan pure lysothrombusase in the treatment of acute cerebral infarct

WU Yun-Xia, ZHAO Min, ZHANG Qing-Chun, ZHAO Yun

2002, 7(4):  353-354. 

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Comparison between esmolol and fentanyl in the prevention of cardiovascular reactions of endotracheal intubation

ZHANG Chuang-Xiang

2002, 7(4):  355-356. 

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Selection of drugs in the treatment of acute cerebral infarction

GUO Zhong

2002, 7(4):  357-358. 

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Relationship of secondary obstinate hiccup,and hypocalcemia and hypomagnesemia in the patients of acute stoke

ZHAO Kun, HE Zhen-Fen, SU Hong-Jun

2002, 7(4):  359-360. 

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Clinical analysis of 40 cases of patients with brain stem hemorrhage

TIAN Chao-Yang, SUI Yong-Zhi

2002, 7(4):  361-362. 

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Clinical evaluation of subarachnoid punctures in treatment of ventricles homrrhage

ZHAO Wu-Li, DU Xu-Chang, CHENG Xiang-Bin

2002, 7(4):  363-364. 

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Analysis on the locus size and position of the patients of acute cerebral vascular disease with the EKG of the patients

SHEN Jian, XIE Peng-Fei, SHEN Xiang-Jun

2002, 7(4):  365-366. 

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Clinical analysis of the etiological evoking factors of cerebral vascular accident

CHEN Bang-Ji, DAI Shu-Hui

2002, 7(4):  367-368. 

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Evaluation of the undoubled-blind design in the clinical trial of Chinese herb

JIANG Meng, XIONG Ning-Ning

2002, 7(4):  369-371. 

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Bias in undoubled-blind design in the clinical trial of Chinese herb affects the evaluation of efficacy and safety. With two examples, the paper recommended a “segregation” technique to minimize the bias in investigators during undoubled-blind trial. The results showed that this method combined other strict means can achieve the conclusions the same as a double-blind trial.

Inhibitor of apoptosis protein and strategy of tumor therapy

MA Jing, YUAN Shou-Jun

2002, 7(4):  372-376. 

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Apoptosis is a cell suicide process with a major role in development and homeostasis in bodies. Dysregulation of apoptosis, involved with inhibitors of apoptosis ( IAPs), contributes a variety of disease states including cancer. The recent progress of members of IAPs family and the anticancer strategy against IAPs is reviewed in this paper.

Inhalation chemotherapy and immunotherapy for respiratory neoplasm

LIU Bao-Rui, QIAN Xiao-Ping

2002, 7(4):  377-380. 

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Inhalation chemotherapy and immunotherapy is a developed technique for respiratory neoplasm recently. It is easy-manipulated with high local response and little side-effects. The drugs include 5-FU, DDP, taxol, camptothecin, interleukin-2 and GM-CSF, etc. Inhalation chemotherapy and immunotherapy have been successfully applied for the therapy of primary lung cancer as well as the lung metastases other tumor.

Actualities of pharmacological effects and clinical application of propolis on oral cavity diseases

LIU Hai-Peng, WANG Qin-Mao

2002, 7(4):  381-384. 

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AIM: This paper summarized the actions of propolis on anti-pathogen, anti-inflammation, analgesia, anti-ulcer, sedation, narcosis and so on. An evaluation of the pharmacological effects, and toxicity was also made. In addition, the clinical applications of propolis on oral cavity diseases were induced, such as dental caries, tooth damages, dental pulp diseases, periodontium diseases, and oral mucosa diseases. This article also prospected the distinctive advantages and application foreground of propolis as a kind of high-efficiency natural medicinal material.