Abstract: AIM: To investigate the nasal absorption of ligustrazine and promotion action of synthetic borneol. METHODS: In situ nasal recirculation method was used to study the dose-effect relationship of nasal absorption of ligustrazine and the effect of synthetic borneol on nasal absorption of ligustrazine in rats. RESULTS: When the concentrations of ligustrazine were 0.25, 0.75, and 1.25g·L^-1in circulation liquid, respectively, the corresponding values of the absorption rate constant k were 0.0195, 0.0227, and 0.0241 min^-1.However, when the concentrations were 2.5 and 5.0 g·L^-1 in circulation liquid, the absorption rate constant k lowered with the concentration being added. CONCLUSION: Ligustrazine can be absorbed through the nasal mucous and synthetic borneol can promote the absorption.

Key words: ligustrazine, synthetic borneol, nasal absorption, absorption rate constant